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FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B Lymphopoiesis.

Jensen, Christina LU ; Kharazi, Shabnam LU ; Böiers, Charlotta LU ; Cheng, Min LU ; Lübking, Anna LU ; Sitnicka Quinn, Ewa LU and Jacobsen, Sten Eirik W LU (2008) In Blood 112. p.2297-2304
Abstract
Phenotypically and functionally distinct progenitors and developmental pathways have been proposed to exist for fetally-derived B-1 and conventional B-2 cells. Although IL-7 appears to be the primary regulator of fetal and adult B lymphopoiesis in mice, considerable fetal B lymphopoiesis and postnatal B-cells are sustained in the absence of IL-7, and in man B-cell generation is suggested to be largely or entirely IL-7-independent, as severe combined immune-deficient patients with IL-7-deficiency appear to have normal B-cell numbers. However, the role of other cytokines in IL-7-independent B lymphopoiesis remains to be established. Although thymic stromal lymphopoietin (TSLP) has been proposed to be the main factor driving IL-7-independent... (More)
Phenotypically and functionally distinct progenitors and developmental pathways have been proposed to exist for fetally-derived B-1 and conventional B-2 cells. Although IL-7 appears to be the primary regulator of fetal and adult B lymphopoiesis in mice, considerable fetal B lymphopoiesis and postnatal B-cells are sustained in the absence of IL-7, and in man B-cell generation is suggested to be largely or entirely IL-7-independent, as severe combined immune-deficient patients with IL-7-deficiency appear to have normal B-cell numbers. However, the role of other cytokines in IL-7-independent B lymphopoiesis remains to be established. Although thymic stromal lymphopoietin (TSLP) has been proposed to be the main factor driving IL-7-independent B lymphopoiesis, and to distinguish fetal from adult B-cell progenitor development in mice, recent studies failed to support a primary role of TSLP in IL-7-independent fetal B-cell development. However, the role of TSLP in IL-7-independent adult B lymphopoiesis and in particular in regulation of B-1 cells remains to be established. Herein, we demonstrate that rather than TSLP, IL-7 and FLT3 ligand (FLT3L) are combined responsible for all B-cell generation in mice, including recently identified B-1-specified cell progenitors. Thus, the same IL-7 and FLT3L-mediated signaling regulate alternative cellular pathways of fetal and adult B-1 and B-2 B lymphopoiesis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
112
pages
2297 - 2304
publisher
American Society of Hematology
external identifiers
  • wos:000259088000024
  • pmid:18566323
  • scopus:55249106981
ISSN
1528-0020
DOI
10.1182/blood-2008-04-150508
language
English
LU publication?
yes
id
8d39f432-be06-41ea-a30a-ecfa2af790aa (old id 1168658)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18566323?dopt=Abstract
date added to LUP
2008-07-02 14:58:16
date last changed
2017-06-11 04:39:55
@article{8d39f432-be06-41ea-a30a-ecfa2af790aa,
  abstract     = {Phenotypically and functionally distinct progenitors and developmental pathways have been proposed to exist for fetally-derived B-1 and conventional B-2 cells. Although IL-7 appears to be the primary regulator of fetal and adult B lymphopoiesis in mice, considerable fetal B lymphopoiesis and postnatal B-cells are sustained in the absence of IL-7, and in man B-cell generation is suggested to be largely or entirely IL-7-independent, as severe combined immune-deficient patients with IL-7-deficiency appear to have normal B-cell numbers. However, the role of other cytokines in IL-7-independent B lymphopoiesis remains to be established. Although thymic stromal lymphopoietin (TSLP) has been proposed to be the main factor driving IL-7-independent B lymphopoiesis, and to distinguish fetal from adult B-cell progenitor development in mice, recent studies failed to support a primary role of TSLP in IL-7-independent fetal B-cell development. However, the role of TSLP in IL-7-independent adult B lymphopoiesis and in particular in regulation of B-1 cells remains to be established. Herein, we demonstrate that rather than TSLP, IL-7 and FLT3 ligand (FLT3L) are combined responsible for all B-cell generation in mice, including recently identified B-1-specified cell progenitors. Thus, the same IL-7 and FLT3L-mediated signaling regulate alternative cellular pathways of fetal and adult B-1 and B-2 B lymphopoiesis.},
  author       = {Jensen, Christina and Kharazi, Shabnam and Böiers, Charlotta and Cheng, Min and Lübking, Anna and Sitnicka Quinn, Ewa and Jacobsen, Sten Eirik W},
  issn         = {1528-0020},
  language     = {eng},
  pages        = {2297--2304},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B Lymphopoiesis.},
  url          = {http://dx.doi.org/10.1182/blood-2008-04-150508},
  volume       = {112},
  year         = {2008},
}