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IL-21 and autoimmune disease - hypothesis and reality?

Holmdahl, Rikard LU (2008) In European Journal of Immunology 38(7). p.1800-1802
Abstract
Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.See accompanying article: http://dx.doi.org/10.1002/eji.200838511.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Immunology
volume
38
issue
7
pages
1800 - 1802
publisher
John Wiley & Sons
external identifiers
  • wos:000257826300003
  • pmid:18546147
  • scopus:50549103219
ISSN
1521-4141
DOI
10.1002/eji.200838529
language
English
LU publication?
yes
id
be1dfaec-5c4c-47f7-9aff-b9355b5eb33a (old id 1168906)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18546147?dopt=Abstract
date added to LUP
2008-07-04 09:43:25
date last changed
2017-01-01 07:33:20
@article{be1dfaec-5c4c-47f7-9aff-b9355b5eb33a,
  abstract     = {Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.See accompanying article: http://dx.doi.org/10.1002/eji.200838511.},
  author       = {Holmdahl, Rikard},
  issn         = {1521-4141},
  language     = {eng},
  number       = {7},
  pages        = {1800--1802},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {IL-21 and autoimmune disease - hypothesis and reality?},
  url          = {http://dx.doi.org/10.1002/eji.200838529},
  volume       = {38},
  year         = {2008},
}