IL-21 and autoimmune disease - hypothesis and reality?
(2008) In European Journal of Immunology 38(7). p.1800-1802- Abstract
- Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.See accompanying article: http://dx.doi.org/10.1002/eji.200838511.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1168906
- author
- Holmdahl, Rikard LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Immunology
- volume
- 38
- issue
- 7
- pages
- 1800 - 1802
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000257826300003
- pmid:18546147
- scopus:50549103219
- pmid:18546147
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200838529
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- be1dfaec-5c4c-47f7-9aff-b9355b5eb33a (old id 1168906)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18546147?dopt=Abstract
- date added to LUP
- 2016-04-04 07:48:17
- date last changed
- 2022-03-15 07:25:14
@article{be1dfaec-5c4c-47f7-9aff-b9355b5eb33a,
abstract = {{Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown that IL-21 and/or IL-21R play no role in Th17 development or autoimmune inflammatory disease. The reasons for these contradictory data are discussed in this Commentary.See accompanying article: http://dx.doi.org/10.1002/eji.200838511.}},
author = {{Holmdahl, Rikard}},
issn = {{1521-4141}},
language = {{eng}},
number = {{7}},
pages = {{1800--1802}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Immunology}},
title = {{IL-21 and autoimmune disease - hypothesis and reality?}},
url = {{http://dx.doi.org/10.1002/eji.200838529}},
doi = {{10.1002/eji.200838529}},
volume = {{38}},
year = {{2008}},
}