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The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update.

Lyssenko, Valeriya LU (2008) In Current Opinion in Clinical Nutrition and Metabolic Care 11(4). p.385-392
Abstract
PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. RECENT FINDINGS: An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type 2 diabetes in almost all populations studied. This gene has since then emerged as the most important type 2 diabetes gene. Genetic variants in transcription factor 7 like-2 confer a strong risk of type 2 diabetes possibly mediated by altering expression of transcription factor 7 like-2 in pancreatic islets. Risk variants in the transcription... (More)
PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. RECENT FINDINGS: An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type 2 diabetes in almost all populations studied. This gene has since then emerged as the most important type 2 diabetes gene. Genetic variants in transcription factor 7 like-2 confer a strong risk of type 2 diabetes possibly mediated by altering expression of transcription factor 7 like-2 in pancreatic islets. Risk variants in the transcription factor 7 like-2 influence insulin secretions both in vitro and in vivo. The risk T allele of this single nucleotide polymorphism also seems to have effects on the enteroinsular axis and the relationship between the incretin hormone glucose-dependent insulinotropic peptide and its target hormones, glucagon and insulin. Given transcription factor 7 like-2s' central role in the Wnt signaling pathway, it would be important to define whether the variant is associated with increased or decreased Wnt signaling. SUMMARY: The fact that transcription factor 7 like-2 is by far the strongest type 2 diabetes susceptibility gene to date emphasizes the importance of exploring the potential of manipulating this pathway in future treatment of the disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Clinical Nutrition and Metabolic Care
volume
11
issue
4
pages
385 - 392
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000259662400005
  • pmid:18541996
  • scopus:54049088180
ISSN
1363-1950
DOI
10.1097/MCO.0b013e328304d970
language
English
LU publication?
yes
id
38a0da16-0476-4a6d-a364-bb84c60f4318 (old id 1168942)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18541996?dopt=Abstract
date added to LUP
2008-07-03 11:13:46
date last changed
2017-10-01 05:02:35
@article{38a0da16-0476-4a6d-a364-bb84c60f4318,
  abstract     = {PURPOSE OF REVIEW: The purpose of this review is to provide a comprehensive evaluation of the most important type 2 diabetes gene to date, transcription factor 7 like-2. RECENT FINDINGS: An important step to find genetic causes of type 2 diabetes in 2006 was the identification of the fact that variants in the gene encoding transcription factor 7 like-2 reproducibly increase susceptibility to type 2 diabetes in almost all populations studied. This gene has since then emerged as the most important type 2 diabetes gene. Genetic variants in transcription factor 7 like-2 confer a strong risk of type 2 diabetes possibly mediated by altering expression of transcription factor 7 like-2 in pancreatic islets. Risk variants in the transcription factor 7 like-2 influence insulin secretions both in vitro and in vivo. The risk T allele of this single nucleotide polymorphism also seems to have effects on the enteroinsular axis and the relationship between the incretin hormone glucose-dependent insulinotropic peptide and its target hormones, glucagon and insulin. Given transcription factor 7 like-2s' central role in the Wnt signaling pathway, it would be important to define whether the variant is associated with increased or decreased Wnt signaling. SUMMARY: The fact that transcription factor 7 like-2 is by far the strongest type 2 diabetes susceptibility gene to date emphasizes the importance of exploring the potential of manipulating this pathway in future treatment of the disease.},
  author       = {Lyssenko, Valeriya},
  issn         = {1363-1950},
  language     = {eng},
  number       = {4},
  pages        = {385--392},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Clinical Nutrition and Metabolic Care},
  title        = {The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update.},
  url          = {http://dx.doi.org/10.1097/MCO.0b013e328304d970},
  volume       = {11},
  year         = {2008},
}