Advanced

Early days of APC resistance and FV Leiden.

Dahlbäck, Björn LU (2008) In Hämostaseologie 28(3). p.103-103
Abstract
Venous thrombosis is a major medical problem annually affecting millions of individuals worldwide. It is a typical multifactorial disease, the pathogenesis involving both environmental and genetic risk factors. A single point mutation in the gene of coagulation factor V (FV), which results in the replacement of Arg506 with a Gln (FV Leiden) is the most common genetic risk factor known to date. The anticoagulant activated protein C (APC) regulates the activity of FVa by cleaving several sites in FVa, and the Arg506 is one of them. APC resistance, which is the consequence of the FV Arg506Gln mutation, results a lifelong hypercoagulable state that increases the risk of thrombosis. APC resistance was discovered in my laboratory and the first... (More)
Venous thrombosis is a major medical problem annually affecting millions of individuals worldwide. It is a typical multifactorial disease, the pathogenesis involving both environmental and genetic risk factors. A single point mutation in the gene of coagulation factor V (FV), which results in the replacement of Arg506 with a Gln (FV Leiden) is the most common genetic risk factor known to date. The anticoagulant activated protein C (APC) regulates the activity of FVa by cleaving several sites in FVa, and the Arg506 is one of them. APC resistance, which is the consequence of the FV Arg506Gln mutation, results a lifelong hypercoagulable state that increases the risk of thrombosis. APC resistance was discovered in my laboratory and the first paper was published in 1993. This was the starting point for an avalanche of research in many laboratories and several thousands of articles have been published since on this topic. The medical community amazingly quickly accepted the concept of APC resistance/FV Leiden as a major risk factor for thrombosis and millions of individuals are today tested for this condition. This review is a personal historical annotation about the early days of APC resistance. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hämostaseologie
volume
28
issue
3
pages
103 - 103
publisher
Schattauer
external identifiers
  • WOS:000262996200002
  • PMID:18521487
  • Scopus:46749126241
ISSN
0720-9355
language
English
LU publication?
yes
id
e5d245c2-6613-4bc5-b9f4-224bf23bf13d (old id 1169217)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18521487?dopt=Abstract
date added to LUP
2008-07-02 14:11:03
date last changed
2017-01-01 07:54:14
@article{e5d245c2-6613-4bc5-b9f4-224bf23bf13d,
  abstract     = {Venous thrombosis is a major medical problem annually affecting millions of individuals worldwide. It is a typical multifactorial disease, the pathogenesis involving both environmental and genetic risk factors. A single point mutation in the gene of coagulation factor V (FV), which results in the replacement of Arg506 with a Gln (FV Leiden) is the most common genetic risk factor known to date. The anticoagulant activated protein C (APC) regulates the activity of FVa by cleaving several sites in FVa, and the Arg506 is one of them. APC resistance, which is the consequence of the FV Arg506Gln mutation, results a lifelong hypercoagulable state that increases the risk of thrombosis. APC resistance was discovered in my laboratory and the first paper was published in 1993. This was the starting point for an avalanche of research in many laboratories and several thousands of articles have been published since on this topic. The medical community amazingly quickly accepted the concept of APC resistance/FV Leiden as a major risk factor for thrombosis and millions of individuals are today tested for this condition. This review is a personal historical annotation about the early days of APC resistance.},
  author       = {Dahlbäck, Björn},
  issn         = {0720-9355},
  language     = {eng},
  number       = {3},
  pages        = {103--103},
  publisher    = {Schattauer},
  series       = {Hämostaseologie},
  title        = {Early days of APC resistance and FV Leiden.},
  volume       = {28},
  year         = {2008},
}