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Increased Prevalence of HTLV-1 in Patients With Pulmonary Tuberculosis Coinfected With HIV, but Not in HIV-Negative Patients With Tuberculosis.

Norrgren, Hans LU ; Bamba, Sana; Larsen, Olav; Silva, Zacarias; Aaby, Peter; Koivula, Tuija and Andersson, Sören (2008) In Journal of Acquired Immune Deficiency Syndromes 48. p.607-610
Abstract
BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly... (More)
BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P < 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). CONCLUSIONS:: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Acquired Immune Deficiency Syndromes
volume
48
pages
607 - 610
external identifiers
  • WOS:000258082200014
  • PMID:18645510
  • Scopus:50949122399
ISSN
1525-4135
DOI
10.1097/QAI.0b013e31817efb83
language
English
LU publication?
yes
id
9bc4e803-7817-41ab-9bf7-adeb0c817dee (old id 1180921)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18645510?dopt=Abstract
date added to LUP
2008-08-07 13:36:37
date last changed
2017-01-01 07:43:24
@article{9bc4e803-7817-41ab-9bf7-adeb0c817dee,
  abstract     = {BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P &lt; 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). CONCLUSIONS:: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals.},
  author       = {Norrgren, Hans and Bamba, Sana and Larsen, Olav and Silva, Zacarias and Aaby, Peter and Koivula, Tuija and Andersson, Sören},
  issn         = {1525-4135},
  language     = {eng},
  pages        = {607--610},
  series       = {Journal of Acquired Immune Deficiency Syndromes},
  title        = {Increased Prevalence of HTLV-1 in Patients With Pulmonary Tuberculosis Coinfected With HIV, but Not in HIV-Negative Patients With Tuberculosis.},
  url          = {http://dx.doi.org/10.1097/QAI.0b013e31817efb83},
  volume       = {48},
  year         = {2008},
}