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Sonographic visualization of the rectoanal inhibitory reflex in children suspected of having hirschsprung disease: a pilot study.

Örnö, Ann-Kristin LU ; Lövkvist, Håkan LU ; Marsal, Karel LU ; Vult von Steyern, Fredrik LU and Arnbjörnsson, Einar LU (2008) In Journal of Ultrasound in Medicine 27(8). p.1165-1169
Abstract
OBJECTIVE: To date, for detection of the absence of peristalsis in children with chronic constipation and a suspicion of Hirschsprung disease (HD), children have been investigated with a contrast enema. If the radiographic investigation is inconclusive, anometry and a rectal biopsy are performed. A new noninvasive real-time sonographic method for examination of the rectoanal inhibitory reflex (RAIR) was compared with anometry. METHODS: The rectum and anal canal of children were visualized transperineally on sonography. The RAIR was elicited by injecting water into the rectum, and the events in the bowel were recorded on video for offline analysis. RESULTS: Injection of water initiated a peristaltic wave that moved the rectal contents into... (More)
OBJECTIVE: To date, for detection of the absence of peristalsis in children with chronic constipation and a suspicion of Hirschsprung disease (HD), children have been investigated with a contrast enema. If the radiographic investigation is inconclusive, anometry and a rectal biopsy are performed. A new noninvasive real-time sonographic method for examination of the rectoanal inhibitory reflex (RAIR) was compared with anometry. METHODS: The rectum and anal canal of children were visualized transperineally on sonography. The RAIR was elicited by injecting water into the rectum, and the events in the bowel were recorded on video for offline analysis. RESULTS: Injection of water initiated a peristaltic wave that moved the rectal contents into the proximal part of the anal canal in healthy children. Among 28 children with suspected HD, 3 showed aganglionosis in their biopsy samples. These 3 children lacked the RAIR according to both sonography and anometry. Both methods had a negative predictive value of 100%. In 17 children, the RAIR was present according to both sonography and anometry, and all of these children had normal histologic findings. In 8 children, sonography did not show the reflex despite normal histologic findings; in 2 of these, the quality of the investigation made the evaluation uncertain. CONCLUSIONS: This pilot study indicates that in children with chronic constipation, a transperineal sonographic examination of the RAIR is comparable to anometry and can facilitate the diagnose of HD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Ultrasound in Medicine
volume
27
issue
8
pages
1165 - 1169
publisher
American Institute of Ultrasound in Medicine
external identifiers
  • wos:000258088100005
  • pmid:18645074
  • scopus:48949092944
ISSN
1550-9613
language
English
LU publication?
yes
id
b2e1866f-5e6f-4ff0-8760-d8b92d96001d (old id 1180931)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18645074?dopt=Abstract
date added to LUP
2008-08-07 13:08:11
date last changed
2017-10-22 04:53:42
@article{b2e1866f-5e6f-4ff0-8760-d8b92d96001d,
  abstract     = {OBJECTIVE: To date, for detection of the absence of peristalsis in children with chronic constipation and a suspicion of Hirschsprung disease (HD), children have been investigated with a contrast enema. If the radiographic investigation is inconclusive, anometry and a rectal biopsy are performed. A new noninvasive real-time sonographic method for examination of the rectoanal inhibitory reflex (RAIR) was compared with anometry. METHODS: The rectum and anal canal of children were visualized transperineally on sonography. The RAIR was elicited by injecting water into the rectum, and the events in the bowel were recorded on video for offline analysis. RESULTS: Injection of water initiated a peristaltic wave that moved the rectal contents into the proximal part of the anal canal in healthy children. Among 28 children with suspected HD, 3 showed aganglionosis in their biopsy samples. These 3 children lacked the RAIR according to both sonography and anometry. Both methods had a negative predictive value of 100%. In 17 children, the RAIR was present according to both sonography and anometry, and all of these children had normal histologic findings. In 8 children, sonography did not show the reflex despite normal histologic findings; in 2 of these, the quality of the investigation made the evaluation uncertain. CONCLUSIONS: This pilot study indicates that in children with chronic constipation, a transperineal sonographic examination of the RAIR is comparable to anometry and can facilitate the diagnose of HD.},
  author       = {Örnö, Ann-Kristin and Lövkvist, Håkan and Marsal, Karel and Vult von Steyern, Fredrik and Arnbjörnsson, Einar},
  issn         = {1550-9613},
  language     = {eng},
  number       = {8},
  pages        = {1165--1169},
  publisher    = {American Institute of Ultrasound in Medicine},
  series       = {Journal of Ultrasound in Medicine},
  title        = {Sonographic visualization of the rectoanal inhibitory reflex in children suspected of having hirschsprung disease: a pilot study.},
  volume       = {27},
  year         = {2008},
}