Advanced

Genes and type 2 diabetes mellitus.

Groop, Leif LU and Lyssenko, Valeriya (2008) In Current Diabetes Reports 8(3). p.192-197
Abstract
In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently... (More)
In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Diabetes Reports
volume
8
issue
3
pages
192 - 197
publisher
Current Science inc.
external identifiers
  • wos:000261100400005
  • pmid:18625115
ISSN
1539-0829
language
English
LU publication?
yes
id
3ee55731-fcf4-46a4-9964-3414ae8dad6a (old id 1181171)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18625115?dopt=Abstract
date added to LUP
2008-08-08 15:54:32
date last changed
2016-04-16 05:47:55
@article{3ee55731-fcf4-46a4-9964-3414ae8dad6a,
  abstract     = {In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.},
  author       = {Groop, Leif and Lyssenko, Valeriya},
  issn         = {1539-0829},
  language     = {eng},
  number       = {3},
  pages        = {192--197},
  publisher    = {Current Science inc.},
  series       = {Current Diabetes Reports},
  title        = {Genes and type 2 diabetes mellitus.},
  volume       = {8},
  year         = {2008},
}