Genes and type 2 diabetes mellitus.
(2008) In Current Diabetes Reports 8(3). p.192-197- Abstract
- In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently... (More)
- In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1181171
- author
- Groop, Leif LU and Lyssenko, Valeriya
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Diabetes Reports
- volume
- 8
- issue
- 3
- pages
- 192 - 197
- publisher
- Current Science, Inc.
- external identifiers
-
- wos:000261100400005
- pmid:18625115
- scopus:52649133436
- ISSN
- 1539-0829
- language
- English
- LU publication?
- yes
- id
- 3ee55731-fcf4-46a4-9964-3414ae8dad6a (old id 1181171)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18625115?dopt=Abstract
- date added to LUP
- 2016-04-04 07:48:45
- date last changed
- 2024-01-03 14:12:19
@article{3ee55731-fcf4-46a4-9964-3414ae8dad6a,
abstract = {{In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease's genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one's lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.}},
author = {{Groop, Leif and Lyssenko, Valeriya}},
issn = {{1539-0829}},
language = {{eng}},
number = {{3}},
pages = {{192--197}},
publisher = {{Current Science, Inc.}},
series = {{Current Diabetes Reports}},
title = {{Genes and type 2 diabetes mellitus.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/18625115?dopt=Abstract}},
volume = {{8}},
year = {{2008}},
}