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Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis.

Eriksson, Mikael LU ; Hardell, Lennart; Carlberg, Michael and Åkerman, Måns LU (2008) In International Journal of Cancer 123(7). p.1657-1663
Abstract
We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnaire. In total 910 (91 %) cases and 1016 (92%) controls participated. Exposure to herbicides gave odds ratio (OR) 1.72, 95% confidence interval (CI) 1.18-2.51. Regarding phenoxyacetic acids highest risk was calculated for MCPA; OR 2.81, 95% CI 1.27-6.22, all these cases had a latency period >10 years. Exposure to glyphosate gave OR 2.02, 95% CI 1.10-3.71 and with >10 years latency... (More)
We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnaire. In total 910 (91 %) cases and 1016 (92%) controls participated. Exposure to herbicides gave odds ratio (OR) 1.72, 95% confidence interval (CI) 1.18-2.51. Regarding phenoxyacetic acids highest risk was calculated for MCPA; OR 2.81, 95% CI 1.27-6.22, all these cases had a latency period >10 years. Exposure to glyphosate gave OR 2.02, 95% CI 1.10-3.71 and with >10 years latency period OR 2.26, 95% CI 1.16-4.40. Insecticides overall gave OR 1.28, 95% CI 0.96-1.72 and impregnating agents OR 1.57, 95% CI 1.07-2.30. Results are also presented for different entities of NHL. In conclusion our study confirmed an association between exposure to phenoxyacetic acids and NHL and the association with glyphosate was considerably strengthened. (c) 2008 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
123
issue
7
pages
1657 - 1663
publisher
John Wiley & Sons
external identifiers
  • wos:000258892500023
  • pmid:18623080
  • scopus:50549098664
ISSN
0020-7136
DOI
10.1002/ijc.23589
language
English
LU publication?
yes
id
78285c6a-0030-4109-a3c8-acc31c11f585 (old id 1181197)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18623080?dopt=Abstract
date added to LUP
2008-08-08 16:01:36
date last changed
2017-08-27 05:46:10
@article{78285c6a-0030-4109-a3c8-acc31c11f585,
  abstract     = {We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnaire. In total 910 (91 %) cases and 1016 (92%) controls participated. Exposure to herbicides gave odds ratio (OR) 1.72, 95% confidence interval (CI) 1.18-2.51. Regarding phenoxyacetic acids highest risk was calculated for MCPA; OR 2.81, 95% CI 1.27-6.22, all these cases had a latency period >10 years. Exposure to glyphosate gave OR 2.02, 95% CI 1.10-3.71 and with >10 years latency period OR 2.26, 95% CI 1.16-4.40. Insecticides overall gave OR 1.28, 95% CI 0.96-1.72 and impregnating agents OR 1.57, 95% CI 1.07-2.30. Results are also presented for different entities of NHL. In conclusion our study confirmed an association between exposure to phenoxyacetic acids and NHL and the association with glyphosate was considerably strengthened. (c) 2008 Wiley-Liss, Inc.},
  author       = {Eriksson, Mikael and Hardell, Lennart and Carlberg, Michael and Åkerman, Måns},
  issn         = {0020-7136},
  language     = {eng},
  number       = {7},
  pages        = {1657--1663},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis.},
  url          = {http://dx.doi.org/10.1002/ijc.23589},
  volume       = {123},
  year         = {2008},
}