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Increased plasma levels of ss(2)-microglobulin, cystatin C and ss-trace protein in term pregnancy are not due to utero-placental production.

Kristensen, Karl LU ; Strevens, Helena LU ; Lindström, Veronica LU ; Grubb, Anders LU and Wide-Swensson, Dag LU (2008) In Scandinavian Journal of Clinical & Laboratory Investigation 68. p.649-653
Abstract
Objective . To study concentration gradients of the low molecular mass proteins, ss(2)-microglobulin, cystatin C and ss-trace protein, between the uterine and ante-cubital veins, the umbilical artery and vein and in the amniotic fluid compartment. Material and methods. The study comprised 27 healthy women with uncomplicated pregnancies undergoing caesarean section at term. Samples were collected simultaneously and paired t-tests were used to compare mean plasma concentrations. Results . There was no significant concentration gradient in the plasma levels of ss(2)-microglobulin, cystatin C or ss-trace protein between the uterine and antecubital veins. There were no correlations between the protein levels in the compartments. Conclusion .... (More)
Objective . To study concentration gradients of the low molecular mass proteins, ss(2)-microglobulin, cystatin C and ss-trace protein, between the uterine and ante-cubital veins, the umbilical artery and vein and in the amniotic fluid compartment. Material and methods. The study comprised 27 healthy women with uncomplicated pregnancies undergoing caesarean section at term. Samples were collected simultaneously and paired t-tests were used to compare mean plasma concentrations. Results . There was no significant concentration gradient in the plasma levels of ss(2)-microglobulin, cystatin C or ss-trace protein between the uterine and antecubital veins. There were no correlations between the protein levels in the compartments. Conclusion . The utero-placental unit does not contribute significantly to the maternal levels of ss(2)-microglobulin, cystatin C and ss-trace protein in normal pregnancy, and the proteins are not likely to be transferred across the placental barrier. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
68
pages
649 - 653
publisher
Informa Healthcare
external identifiers
  • WOS:000260497100020
  • PMID:18609110
  • Scopus:55249105258
ISSN
1502-7686
DOI
10.1080/00365510802007804
language
English
LU publication?
yes
id
f90b8537-4ece-4387-b4ac-a3c2371c7732 (old id 1181397)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18609110?dopt=Abstract
date added to LUP
2008-08-06 16:13:17
date last changed
2017-01-01 07:45:17
@article{f90b8537-4ece-4387-b4ac-a3c2371c7732,
  abstract     = {Objective . To study concentration gradients of the low molecular mass proteins, ss(2)-microglobulin, cystatin C and ss-trace protein, between the uterine and ante-cubital veins, the umbilical artery and vein and in the amniotic fluid compartment. Material and methods. The study comprised 27 healthy women with uncomplicated pregnancies undergoing caesarean section at term. Samples were collected simultaneously and paired t-tests were used to compare mean plasma concentrations. Results . There was no significant concentration gradient in the plasma levels of ss(2)-microglobulin, cystatin C or ss-trace protein between the uterine and antecubital veins. There were no correlations between the protein levels in the compartments. Conclusion . The utero-placental unit does not contribute significantly to the maternal levels of ss(2)-microglobulin, cystatin C and ss-trace protein in normal pregnancy, and the proteins are not likely to be transferred across the placental barrier.},
  author       = {Kristensen, Karl and Strevens, Helena and Lindström, Veronica and Grubb, Anders and Wide-Swensson, Dag},
  issn         = {1502-7686},
  language     = {eng},
  pages        = {649--653},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical & Laboratory Investigation},
  title        = {Increased plasma levels of ss(2)-microglobulin, cystatin C and ss-trace protein in term pregnancy are not due to utero-placental production.},
  url          = {http://dx.doi.org/10.1080/00365510802007804},
  volume       = {68},
  year         = {2008},
}