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Evaluation of continuous and intermittent myocardial topical negative pressure.

Lindstedt Ingemansson, Sandra LU ; Malmsjö, Malin LU ; Gesslein, Bodil LU and Ingemansson, Richard LU (2008) In Journal of Cardiovascular Medicine 9(8). p.813-819
Abstract
OBJECTIVE: Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg. METHODS: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally... (More)
OBJECTIVE: Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg. METHODS: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the left anterior descending artery area at depths of approximately 5-6 mm. Measurements of microvascular blood flow were performed in normal myocardium and ischemic myocardium during 20 min of countinuous and intermittent topical negative pressure at -50 mmHg. RESULTS: Both continuous and intermittent topical negative pressure of -50 mmHg significantly increased microvascular blood flow in the underlying myocardium: from 56.2 +/- 13.1 perfusion units (PU) before to 132.8 +/- 7.4 PU during countinuous topical negative pressure application (P < 0.05) and from 75.8 +/- 12.1 PU before to 153.6 +/- 4.7 PU during intermittent topical negative pressure application (P < 0.05). CONCLUSION: No statistically significant difference was found between microvascular blood flow during 20 min of continuous and intermittent topical negative pressure at -50 mmHg in this porcine model. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiovascular Medicine
volume
9
issue
8
pages
813 - 819
publisher
Lippincott Williams and Wilkins
external identifiers
  • wos:000258046500010
  • pmid:18607247
  • scopus:55949134756
ISSN
1558-2027
DOI
10.2459/JCM.0b013e3282f85bda
language
English
LU publication?
yes
id
e3449f4d-2d04-49f7-ac8b-82f3c50cbc7f (old id 1181485)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18607247?dopt=Abstract
date added to LUP
2008-08-07 13:14:57
date last changed
2017-01-01 07:39:01
@article{e3449f4d-2d04-49f7-ac8b-82f3c50cbc7f,
  abstract     = {OBJECTIVE: Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg. METHODS: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the left anterior descending artery area at depths of approximately 5-6 mm. Measurements of microvascular blood flow were performed in normal myocardium and ischemic myocardium during 20 min of countinuous and intermittent topical negative pressure at -50 mmHg. RESULTS: Both continuous and intermittent topical negative pressure of -50 mmHg significantly increased microvascular blood flow in the underlying myocardium: from 56.2 +/- 13.1 perfusion units (PU) before to 132.8 +/- 7.4 PU during countinuous topical negative pressure application (P &lt; 0.05) and from 75.8 +/- 12.1 PU before to 153.6 +/- 4.7 PU during intermittent topical negative pressure application (P &lt; 0.05). CONCLUSION: No statistically significant difference was found between microvascular blood flow during 20 min of continuous and intermittent topical negative pressure at -50 mmHg in this porcine model.},
  author       = {Lindstedt Ingemansson, Sandra and Malmsjö, Malin and Gesslein, Bodil and Ingemansson, Richard},
  issn         = {1558-2027},
  language     = {eng},
  number       = {8},
  pages        = {813--819},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Journal of Cardiovascular Medicine},
  title        = {Evaluation of continuous and intermittent myocardial topical negative pressure.},
  url          = {http://dx.doi.org/10.2459/JCM.0b013e3282f85bda},
  volume       = {9},
  year         = {2008},
}