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Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS)

Ekesbo, Rickard LU ; Nilsson, Peter LU and Sjölund, Kristina LU (2008) In Scandinavian Journal of Primary Health Care 26(2). p.106-110
Abstract
Objective. To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS). Design. A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study. Subjects. Eighty-two patients with IBS were randomized to a diet with either SPC or placebo. Main outcome measures. The overall clinical condition and the quality of life were measured by VAS and SF-36 questionnaire, respectively. The plasma levels of ASF were determined in 14 patients with dominating loose stools before and after diet. Results. All patients significantly (p < 0.001) improved in IBS-related... (More)
Objective. To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS). Design. A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study. Subjects. Eighty-two patients with IBS were randomized to a diet with either SPC or placebo. Main outcome measures. The overall clinical condition and the quality of life were measured by VAS and SF-36 questionnaire, respectively. The plasma levels of ASF were determined in 14 patients with dominating loose stools before and after diet. Results. All patients significantly (p < 0.001) improved in IBS-related symptoms irrespective of active or placebo diet. In an active-diet sub-group with diarrhoea (n = 11) there was a significant (p < 0.05) correlation between the increase of plasma ASF level and the improvement on the VAS. Conclusion. Both study groups improved significantly on the VAS but no additive effect was seen for the active treatment. In the sub-group with loose stools, the SPC diet induced ASF plasma levels in IBS patients and was correlated to significant symptom improvement in the individual patient. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
irritable bowel syndrome, diet, family practice, anti-secretory factor
in
Scandinavian Journal of Primary Health Care
volume
26
issue
2
pages
106 - 110
publisher
Taylor & Francis
external identifiers
  • wos:000257081400009
  • scopus:45749084897
ISSN
0281-3432
DOI
10.1080/02813430802005894
language
English
LU publication?
yes
id
88e1563b-862a-4c62-9791-5981539c97da (old id 1186301)
date added to LUP
2008-09-03 14:39:27
date last changed
2017-01-01 04:55:03
@article{88e1563b-862a-4c62-9791-5981539c97da,
  abstract     = {Objective. To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS). Design. A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study. Subjects. Eighty-two patients with IBS were randomized to a diet with either SPC or placebo. Main outcome measures. The overall clinical condition and the quality of life were measured by VAS and SF-36 questionnaire, respectively. The plasma levels of ASF were determined in 14 patients with dominating loose stools before and after diet. Results. All patients significantly (p &lt; 0.001) improved in IBS-related symptoms irrespective of active or placebo diet. In an active-diet sub-group with diarrhoea (n = 11) there was a significant (p &lt; 0.05) correlation between the increase of plasma ASF level and the improvement on the VAS. Conclusion. Both study groups improved significantly on the VAS but no additive effect was seen for the active treatment. In the sub-group with loose stools, the SPC diet induced ASF plasma levels in IBS patients and was correlated to significant symptom improvement in the individual patient.},
  author       = {Ekesbo, Rickard and Nilsson, Peter and Sjölund, Kristina},
  issn         = {0281-3432},
  keyword      = {irritable bowel syndrome,diet,family practice,anti-secretory factor},
  language     = {eng},
  number       = {2},
  pages        = {106--110},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Primary Health Care},
  title        = {Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS)},
  url          = {http://dx.doi.org/10.1080/02813430802005894},
  volume       = {26},
  year         = {2008},
}