A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
(2008) In Molecular Genetics and Metabolism 94(3). p.386-388- Abstract
- Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1186729
- author
- Brorsson, Caroline ; Bergholdt, Regine ; Sjögren, Marketa LU ; Eising, Stefanie ; Sorensen, Karina Meden ; Hougaard, David M. ; Orho-Melander, Marju LU ; Groop, Leif LU and Pociot, Flemming
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- beta-cell function, genetics, type 1 diabetes, SLC30A8, zinc transporter
- in
- Molecular Genetics and Metabolism
- volume
- 94
- issue
- 3
- pages
- 386 - 388
- publisher
- Elsevier
- external identifiers
-
- wos:000257225700019
- scopus:44649196388
- ISSN
- 1096-7192
- DOI
- 10.1016/j.ymgme.2008.02.011
- language
- English
- LU publication?
- yes
- id
- f32415a8-a4b1-4c7b-8df3-1d5c927d00c6 (old id 1186729)
- date added to LUP
- 2016-04-01 11:56:53
- date last changed
- 2024-01-08 02:28:09
@article{f32415a8-a4b1-4c7b-8df3-1d5c927d00c6, abstract = {{Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.}}, author = {{Brorsson, Caroline and Bergholdt, Regine and Sjögren, Marketa and Eising, Stefanie and Sorensen, Karina Meden and Hougaard, David M. and Orho-Melander, Marju and Groop, Leif and Pociot, Flemming}}, issn = {{1096-7192}}, keywords = {{beta-cell function; genetics; type 1 diabetes; SLC30A8; zinc transporter}}, language = {{eng}}, number = {{3}}, pages = {{386--388}}, publisher = {{Elsevier}}, series = {{Molecular Genetics and Metabolism}}, title = {{A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population}}, url = {{http://dx.doi.org/10.1016/j.ymgme.2008.02.011}}, doi = {{10.1016/j.ymgme.2008.02.011}}, volume = {{94}}, year = {{2008}}, }