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A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Brorsson, Caroline ; Bergholdt, Regine ; Sjögren, Marketa LU ; Eising, Stefanie ; Sorensen, Karina Meden ; Hougaard, David M. ; Orho-Melander, Marju LU ; Groop, Leif LU and Pociot, Flemming (2008) In Molecular Genetics and Metabolism 94(3). p.386-388
Abstract
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta-cell function, genetics, type 1 diabetes, SLC30A8, zinc transporter
in
Molecular Genetics and Metabolism
volume
94
issue
3
pages
386 - 388
publisher
Elsevier
external identifiers
  • wos:000257225700019
  • scopus:44649196388
ISSN
1096-7192
DOI
10.1016/j.ymgme.2008.02.011
language
English
LU publication?
yes
id
f32415a8-a4b1-4c7b-8df3-1d5c927d00c6 (old id 1186729)
date added to LUP
2016-04-01 11:56:53
date last changed
2024-01-08 02:28:09
@article{f32415a8-a4b1-4c7b-8df3-1d5c927d00c6,
  abstract     = {{Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.}},
  author       = {{Brorsson, Caroline and Bergholdt, Regine and Sjögren, Marketa and Eising, Stefanie and Sorensen, Karina Meden and Hougaard, David M. and Orho-Melander, Marju and Groop, Leif and Pociot, Flemming}},
  issn         = {{1096-7192}},
  keywords     = {{beta-cell function; genetics; type 1 diabetes; SLC30A8; zinc transporter}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{386--388}},
  publisher    = {{Elsevier}},
  series       = {{Molecular Genetics and Metabolism}},
  title        = {{A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population}},
  url          = {{http://dx.doi.org/10.1016/j.ymgme.2008.02.011}},
  doi          = {{10.1016/j.ymgme.2008.02.011}},
  volume       = {{94}},
  year         = {{2008}},
}