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A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Brorsson, Caroline; Bergholdt, Regine; Sjögren, Marketa LU ; Eising, Stefanie; Sorensen, Karina Meden; Hougaard, David M.; Orho-Melander, Marju LU ; Groop, Leif LU and Pociot, Flemming (2008) In Molecular Genetics and Metabolism 94(3). p.386-388
Abstract
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta-cell function, genetics, type 1 diabetes, SLC30A8, zinc transporter
in
Molecular Genetics and Metabolism
volume
94
issue
3
pages
386 - 388
publisher
Elsevier
external identifiers
  • wos:000257225700019
  • scopus:44649196388
ISSN
1096-7192
DOI
10.1016/j.ymgme.2008.02.011
language
English
LU publication?
yes
id
f32415a8-a4b1-4c7b-8df3-1d5c927d00c6 (old id 1186729)
date added to LUP
2008-09-03 16:16:05
date last changed
2017-01-01 04:41:34
@article{f32415a8-a4b1-4c7b-8df3-1d5c927d00c6,
  abstract     = {Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.},
  author       = {Brorsson, Caroline and Bergholdt, Regine and Sjögren, Marketa and Eising, Stefanie and Sorensen, Karina Meden and Hougaard, David M. and Orho-Melander, Marju and Groop, Leif and Pociot, Flemming},
  issn         = {1096-7192},
  keyword      = {beta-cell function,genetics,type 1 diabetes,SLC30A8,zinc transporter},
  language     = {eng},
  number       = {3},
  pages        = {386--388},
  publisher    = {Elsevier},
  series       = {Molecular Genetics and Metabolism},
  title        = {A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population},
  url          = {http://dx.doi.org/10.1016/j.ymgme.2008.02.011},
  volume       = {94},
  year         = {2008},
}