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Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?

da Silva, Zacarias J; Oliveira, Ines; Andersen, Andreas; Dias, Francisco; Rodrigues, Amabelia; Holmgren, Birgitta G LU ; Andersson, Soren and Aaby, Peter (2008) In AIDS 22(10). p.1195-1202
Abstract
Objectives: To assess the changes in HIV prevalence and incidence between 1996 and 2006 in urban areas of Bissau. Design: A cross-sectional survey of 384 randomly selected houses within a community-based follow-up study of HIV-1 and HIV-2. Methods: A total of 3242 individuals aged at least 15 years were eligible for inclusion. Participants were interviewed about behavioral and socio-economic factors and had a blood sample drawn. A total of 2548 individuals were tested for antibodies to HIV-1 and HIV-2, of whom 649 had taken part in a similar survey in 1996. Results: With 0.5% HIV dual reactions included, the overall HIV-1 prevalence was 4.6% (118 out of 2548) and the HIV-2 prevalence was 4.4% (112 out of 2548). The prevalence of HIV-1... (More)
Objectives: To assess the changes in HIV prevalence and incidence between 1996 and 2006 in urban areas of Bissau. Design: A cross-sectional survey of 384 randomly selected houses within a community-based follow-up study of HIV-1 and HIV-2. Methods: A total of 3242 individuals aged at least 15 years were eligible for inclusion. Participants were interviewed about behavioral and socio-economic factors and had a blood sample drawn. A total of 2548 individuals were tested for antibodies to HIV-1 and HIV-2, of whom 649 had taken part in a similar survey in 1996. Results: With 0.5% HIV dual reactions included, the overall HIV-1 prevalence was 4.6% (118 out of 2548) and the HIV-2 prevalence was 4.4% (112 out of 2548). The prevalence of HIV-1 increased more for women than men especially in the 25-34-year age group. HIV-2 prevalence decreased below 45 years of age but not for individuals more than 45 years old. The incidence rate between 1996 and 2006 was 0.5 per 100 person-years for HIV-1 and 0.24 per 100 person-years for HIV-2. Compared with a previous period from 1987 to 1996, the incidence of HIV-2 is declining whereas no significant increase in the incidence of HIV-1 was observed. Conclusions: The present study shows an increasing prevalence of HIV-1 and a decreasing prevalence of HIV-2 in Guinea-Bissau. HIV is generally a bigger problem for women. Despite the general decline in prevalence, HIV-2 may continue as an infection in older people, especially women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prevalence, incidence, HIV-2, HIV-1, community study, Guinea-Bissau
in
AIDS
volume
22
issue
10
pages
1195 - 1202
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000257334900011
  • scopus:50949123267
ISSN
1473-5571
language
English
LU publication?
yes
id
16b036e9-d43b-4176-9499-7ae205419df5 (old id 1187204)
date added to LUP
2008-09-05 09:47:05
date last changed
2017-09-24 03:48:58
@article{16b036e9-d43b-4176-9499-7ae205419df5,
  abstract     = {Objectives: To assess the changes in HIV prevalence and incidence between 1996 and 2006 in urban areas of Bissau. Design: A cross-sectional survey of 384 randomly selected houses within a community-based follow-up study of HIV-1 and HIV-2. Methods: A total of 3242 individuals aged at least 15 years were eligible for inclusion. Participants were interviewed about behavioral and socio-economic factors and had a blood sample drawn. A total of 2548 individuals were tested for antibodies to HIV-1 and HIV-2, of whom 649 had taken part in a similar survey in 1996. Results: With 0.5% HIV dual reactions included, the overall HIV-1 prevalence was 4.6% (118 out of 2548) and the HIV-2 prevalence was 4.4% (112 out of 2548). The prevalence of HIV-1 increased more for women than men especially in the 25-34-year age group. HIV-2 prevalence decreased below 45 years of age but not for individuals more than 45 years old. The incidence rate between 1996 and 2006 was 0.5 per 100 person-years for HIV-1 and 0.24 per 100 person-years for HIV-2. Compared with a previous period from 1987 to 1996, the incidence of HIV-2 is declining whereas no significant increase in the incidence of HIV-1 was observed. Conclusions: The present study shows an increasing prevalence of HIV-1 and a decreasing prevalence of HIV-2 in Guinea-Bissau. HIV is generally a bigger problem for women. Despite the general decline in prevalence, HIV-2 may continue as an infection in older people, especially women.},
  author       = {da Silva, Zacarias J and Oliveira, Ines and Andersen, Andreas and Dias, Francisco and Rodrigues, Amabelia and Holmgren, Birgitta G and Andersson, Soren and Aaby, Peter},
  issn         = {1473-5571},
  keyword      = {prevalence,incidence,HIV-2,HIV-1,community study,Guinea-Bissau},
  language     = {eng},
  number       = {10},
  pages        = {1195--1202},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {AIDS},
  title        = {Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?},
  volume       = {22},
  year         = {2008},
}