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Immune-response against Streptococcus pyogenes in the development of abdominal aortic aneurysm - A population-based case-control study

Wanhainen, A; Rasmussen, M; Björck, Lars LU and Bjorck, M (2008) In Vasa: European Journal of Vascular Medicine 37(2). p.143-149
Abstract (Swedish)
Abstract in German

Hintergrund: Es wurde in einer populationsbasierten Fallkontrollstudie die Assoziation von Antikörpern auf Streptokokkus pyogenes Antigene mit der Entwicklung eines abdomionellen Aortenaneurysma (BAA) untersucht. Patienten und Methoden: 42 Patienten, bei denen ein BAA durch Screnning entdeckt wurde, wurden mit 100 alters- und geschlechtsgleichen Kontrollpatienten mit normaler Aorta verglichen. Es wurden Antikörper gegen drei kürzlich charakterisierte wandständige Proteine von S. pyogenes (SclA, SclB and GRAB) aus Plasmaproben zum Zeitpunkt des Screenings (aktuelle Proben) und solchen, die 12 Jahre zuvor gewonnen wurden (historische Proben), untersucht. Ergebnisse: Historische Antikörperspiegel gegen das... (More)
Abstract in German

Hintergrund: Es wurde in einer populationsbasierten Fallkontrollstudie die Assoziation von Antikörpern auf Streptokokkus pyogenes Antigene mit der Entwicklung eines abdomionellen Aortenaneurysma (BAA) untersucht. Patienten und Methoden: 42 Patienten, bei denen ein BAA durch Screnning entdeckt wurde, wurden mit 100 alters- und geschlechtsgleichen Kontrollpatienten mit normaler Aorta verglichen. Es wurden Antikörper gegen drei kürzlich charakterisierte wandständige Proteine von S. pyogenes (SclA, SclB and GRAB) aus Plasmaproben zum Zeitpunkt des Screenings (aktuelle Proben) und solchen, die 12 Jahre zuvor gewonnen wurden (historische Proben), untersucht. Ergebnisse: Historische Antikörperspiegel gegen das S.pyogenes Antigen GRAB waren in BAA Patienten signifikant höher als bei den Kontrollpersonen (0.25 vs 0.17, p = 0.021). Ein ähnlicher Trend wurde bei den aktuellen GRAB Antikörperspiegeln gesehen (0.23 vs 0.17, p = 0.072). GRAB Antikörperspiegel von Patienten über 60 Jahren behielten in einem logistischen Regressionsmodell ihre Assoziation mit BAA nach Adjustierung für Arterioskleroseanamnese (OR 20.2, p = 0.022), aktuellem Nikotinkonsum (OR 21.4, p = 0.025)und für BAA positiver Familienanamnese (OR 12.9, p = 0.053). Der Vergleich von Antikörperspiegeln gegen SclA und SclB zeigte keine Unterschiede zwischen beiden Gruppen. Zusammenfassung: Die Immunantwort gegen S. pyogenes protein GRAB scheint in die Pathogenese des BAA involviert zu sein. (Less)
Abstract
Background: In a population -based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, ScIB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical). Results: Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with... (More)
Background: In a population -based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, ScIB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical). Results: Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with controls (0.25 vs 0.17, p = 0.021). A similar trend was observed in current GRAB antibody levels (0.23 vs 0. 17, p = 0.072). GRAB-antibody levels at age 60 years retained the association with AAA in a logistic regression model after adjustment for a history of atherosclerosis (OR 20.2, p = 0.022), current smoking (OR 21.4, p = 0.025) and family history of AAA (OR 12.9, p = 0.053). Current and historical antibody levels against ScIA and SclB in AAA patients were similar to those in controls. Conclusions: The results indicate that the immune response against S. pyogenes protein GRAB may be involved in the pathogenesis of AAA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GRAB, immune-response, abdominal aortic aneurysm, Streptococcus pyogenes
in
Vasa: European Journal of Vascular Medicine
volume
37
issue
2
pages
143 - 149
publisher
Hans Huber
external identifiers
  • wos:000256993900006
  • scopus:45849151154
ISSN
0301-1526
DOI
10.1024/0301-1526.37.2.143
language
English
LU publication?
yes
id
8a3b72c9-5562-4397-9124-af5049edb725 (old id 1187213)
date added to LUP
2008-09-05 09:50:21
date last changed
2017-01-01 05:04:08
@article{8a3b72c9-5562-4397-9124-af5049edb725,
  abstract     = {Background: In a population -based case-control study the association between antibodies to Streptococcus pyogenes antigens and the development of abdominal aortic aneurysm (AAA) was analysed. Patients and methods: Forty-two patients with screening-detected AAA were compared to 100 age- and sex matched controls with normal aortas. Antibodies against three recently characterized cell wall-attached proteins of S. pyogenes (SclA, ScIB and GRAB) were analysed in plasma samples obtained at screening (current), and in samples obtained from a study conducted 12 years previously on the same population (historical). Results: Historical antibody levels against the S. pyogenes antigen GRAB were significantly higher in AAA patients compared with controls (0.25 vs 0.17, p = 0.021). A similar trend was observed in current GRAB antibody levels (0.23 vs 0. 17, p = 0.072). GRAB-antibody levels at age 60 years retained the association with AAA in a logistic regression model after adjustment for a history of atherosclerosis (OR 20.2, p = 0.022), current smoking (OR 21.4, p = 0.025) and family history of AAA (OR 12.9, p = 0.053). Current and historical antibody levels against ScIA and SclB in AAA patients were similar to those in controls. Conclusions: The results indicate that the immune response against S. pyogenes protein GRAB may be involved in the pathogenesis of AAA.},
  author       = {Wanhainen, A and Rasmussen, M and Björck, Lars and Bjorck, M},
  issn         = {0301-1526},
  keyword      = {GRAB,immune-response,abdominal aortic aneurysm,Streptococcus pyogenes},
  language     = {eng},
  number       = {2},
  pages        = {143--149},
  publisher    = {Hans Huber},
  series       = {Vasa: European Journal of Vascular Medicine},
  title        = {Immune-response against Streptococcus pyogenes in the development of abdominal aortic aneurysm - A population-based case-control study},
  url          = {http://dx.doi.org/10.1024/0301-1526.37.2.143},
  volume       = {37},
  year         = {2008},
}