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LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake.

Johansson Persson, Anna LU ; Barri, Thaer ; Ulmius, Matilda LU ; Önning, Gunilla LU and Dragsted, Lars Ove (2013) In Analytical and Bioanalytical Chemistry 405(14). p.4799-4809
Abstract
The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were... (More)
The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p < 0.01, q < 0.05). Two markers, 2,6-dihydroxybenzoic acid and 2-aminophenol sulfate, were increased after HF diet, along with a tentatively identified saponin derived from oat avenacosides. The untargeted metabolomics approach enabled the identification of two new markers of dietary fiber intake in human plasma. Further studies will be needed to verify if these markers could serve as compliance markers of fiber intake. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
405
issue
14
pages
4799 - 4809
publisher
Springer
external identifiers
  • wos:000318312400013
  • pmid:23535740
  • scopus:84891690357
  • pmid:23535740
ISSN
1618-2642
DOI
10.1007/s00216-013-6874-5
language
English
LU publication?
yes
id
1190b4b6-97be-473f-8bbd-58fa068bebb3 (old id 3627602)
date added to LUP
2016-04-01 09:57:30
date last changed
2022-01-25 18:21:10
@article{1190b4b6-97be-473f-8bbd-58fa068bebb3,
  abstract     = {{The objective was to investigate the alterations of plasma metabolome profiles to identify exposure and effect markers of dietary fiber intake. Subjects (n = 25) aged 58.6 (1.1) years (mean and SD) with a body mass index of 26.6 (0.5) kg/m(2) were given a high fiber (HF) and a low fiber (LF) diet, in a 5-week randomized controlled crossover intervention. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products, whereas the LF diet was made of equivalent food products to the HF diet, but without adding fibers. Blood plasma samples were collected at the start and end of each intervention period and analyzed by LC-QTOF/MS. In total, 6 features in positive mode and 14 features in negative mode were significantly different between the HF and the LF diet (p &lt; 0.01, q &lt; 0.05). Two markers, 2,6-dihydroxybenzoic acid and 2-aminophenol sulfate, were increased after HF diet, along with a tentatively identified saponin derived from oat avenacosides. The untargeted metabolomics approach enabled the identification of two new markers of dietary fiber intake in human plasma. Further studies will be needed to verify if these markers could serve as compliance markers of fiber intake.}},
  author       = {{Johansson Persson, Anna and Barri, Thaer and Ulmius, Matilda and Önning, Gunilla and Dragsted, Lars Ove}},
  issn         = {{1618-2642}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{4799--4809}},
  publisher    = {{Springer}},
  series       = {{Analytical and Bioanalytical Chemistry}},
  title        = {{LC-QTOF/MS metabolomic profiles in human plasma after a 5-week high dietary fiber intake.}},
  url          = {{http://dx.doi.org/10.1007/s00216-013-6874-5}},
  doi          = {{10.1007/s00216-013-6874-5}},
  volume       = {{405}},
  year         = {{2013}},
}