Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles
Reimhult, Kristina ; Yoshimatsu, Keiichi LU ; Risveden, Klas LU ; Chen, Si ; Ye, Lei LU
and Krozer, Anatol
(2008)
In Biosensors & Bioelectronics
23(12).
p.1908-1914
- Abstract
- Molecularly imprinted polymers (MIPs) are gaining great interest as tailor-made recognition materials for the development of biomimetic sensors. Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly on transducer surfaces. In this work we functionalized quartz crystal microbalance (QCM) sensor crystals by coating the sensing surfaces with pre-made molecularly imprinted nanoparticles. The nanoparticles were immobilized on the QCM transducers by physical entrapment in a thin poly(ethylene terephthalate) (PET) layer that was spin-coated on the transducer surface. By controlling the deposition conditions,... (More)
- Molecularly imprinted polymers (MIPs) are gaining great interest as tailor-made recognition materials for the development of biomimetic sensors. Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly on transducer surfaces. In this work we functionalized quartz crystal microbalance (QCM) sensor crystals by coating the sensing surfaces with pre-made molecularly imprinted nanoparticles. The nanoparticles were immobilized on the QCM transducers by physical entrapment in a thin poly(ethylene terephthalate) (PET) layer that was spin-coated on the transducer surface. By controlling the deposition conditions, it was possible to gain a high nanoparticle loading in a stable PET layer, allowing the recognition sites in nanoparticles to be easily accessed by the test analytes. In this work, different sensor surfaces were studied by micro-profilometry and atomic force microscopy and the functionality was evaluated using quartz crystal microbalance with dissipation (QCM-D). The molecular recognition capability of the sensors were also confirmed using radioligand binding analysis by testing their response to the presence of the test compounds, (R)- and (S)-propranolot in aqueous buffer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1191188
- author
- Reimhult, Kristina
; Yoshimatsu, Keiichi
LU
; Risveden, Klas
LU
; Chen, Si
; Ye, Lei
LU
and Krozer, Anatol
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- molecularly imprinted polymers, quartz crystal microbalance, nanoparticles, sensors
- in
- Biosensors & Bioelectronics
- volume
- 23
- issue
- 12
- pages
- 1908 - 1914
- publisher
- Elsevier
- external identifiers
-
- wos:000256736300027
- scopus:43449083182
- pmid:18374557
- ISSN
- 1873-4235
- DOI
- 10.1016/j.bios.2008.02.011
- language
- English
- LU publication?
- yes
- id
- 6cac8fcd-3c42-4ce6-ac86-4f3877e25ac5 (old id 1191188)
- date added to LUP
- 2016-04-01 14:14:40
- date last changed
- 2022-02-27 01:38:34
@article{6cac8fcd-3c42-4ce6-ac86-4f3877e25ac5,
abstract = {{Molecularly imprinted polymers (MIPs) are gaining great interest as tailor-made recognition materials for the development of biomimetic sensors. Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly on transducer surfaces. In this work we functionalized quartz crystal microbalance (QCM) sensor crystals by coating the sensing surfaces with pre-made molecularly imprinted nanoparticles. The nanoparticles were immobilized on the QCM transducers by physical entrapment in a thin poly(ethylene terephthalate) (PET) layer that was spin-coated on the transducer surface. By controlling the deposition conditions, it was possible to gain a high nanoparticle loading in a stable PET layer, allowing the recognition sites in nanoparticles to be easily accessed by the test analytes. In this work, different sensor surfaces were studied by micro-profilometry and atomic force microscopy and the functionality was evaluated using quartz crystal microbalance with dissipation (QCM-D). The molecular recognition capability of the sensors were also confirmed using radioligand binding analysis by testing their response to the presence of the test compounds, (R)- and (S)-propranolot in aqueous buffer.}},
author = {{Reimhult, Kristina and Yoshimatsu, Keiichi and Risveden, Klas and Chen, Si and Ye, Lei and Krozer, Anatol}},
issn = {{1873-4235}},
keywords = {{molecularly imprinted polymers; quartz crystal microbalance; nanoparticles; sensors}},
language = {{eng}},
number = {{12}},
pages = {{1908--1914}},
publisher = {{Elsevier}},
series = {{Biosensors & Bioelectronics}},
title = {{Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles}},
url = {{http://dx.doi.org/10.1016/j.bios.2008.02.011}},
doi = {{10.1016/j.bios.2008.02.011}},
volume = {{23}},
year = {{2008}},
}