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Abdominal aortic aneurysm and infection with CagA positive strains of Helicobacter pylori

Nyberg, Anders; Skagius, Elisabet; Nilsson, Ingrid LU ; Ljungh, Åsa LU and Henriksson, Anders E (2008) In Scandinavian Journal of Infectious Diseases 40(3). p.204-207
Abstract
The aim of the present study was to investigate whether virulent CagA positive Helicobacter pylori strains are those preferentially related to abdominal aortic aneurysm (AAA) rupture. Several microorganisms have been linked to aneurysm development. Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of AAA. Previous studies have shown increased risk of carotid atherosclerosis and coronary heart disease in subjects harbouring CagA positive strains of H. pylori. The relevance of CagA positive H. pylori involved in the processes underlying aneurysmal development, expansion, and rupture is unknown. In a case-control study, 119 patients with AAA and 36 matched... (More)
The aim of the present study was to investigate whether virulent CagA positive Helicobacter pylori strains are those preferentially related to abdominal aortic aneurysm (AAA) rupture. Several microorganisms have been linked to aneurysm development. Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of AAA. Previous studies have shown increased risk of carotid atherosclerosis and coronary heart disease in subjects harbouring CagA positive strains of H. pylori. The relevance of CagA positive H. pylori involved in the processes underlying aneurysmal development, expansion, and rupture is unknown. In a case-control study, 119 patients with AAA and 36 matched controls were prospectively investigated with H. pylori serology. Patients with ruptured AAA have similar levels of IgG antibodies against H. pylori to patients with electively operated AAA, small AAA, and controls. In conclusion, this study fails to demonstrate a connection between H. pylori CagA seropositivity and abdominal aortic aneurysm rupture. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
40
issue
3
pages
204 - 207
publisher
Informa Healthcare
external identifiers
  • wos:000253335900002
  • scopus:39349102874
ISSN
1651-1980
DOI
10.1080/00365540701642153
language
English
LU publication?
yes
id
918f502e-12d7-4e97-9ff1-5c3a8ae45511 (old id 1193927)
date added to LUP
2008-09-10 10:11:06
date last changed
2017-01-01 05:56:51
@article{918f502e-12d7-4e97-9ff1-5c3a8ae45511,
  abstract     = {The aim of the present study was to investigate whether virulent CagA positive Helicobacter pylori strains are those preferentially related to abdominal aortic aneurysm (AAA) rupture. Several microorganisms have been linked to aneurysm development. Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of AAA. Previous studies have shown increased risk of carotid atherosclerosis and coronary heart disease in subjects harbouring CagA positive strains of H. pylori. The relevance of CagA positive H. pylori involved in the processes underlying aneurysmal development, expansion, and rupture is unknown. In a case-control study, 119 patients with AAA and 36 matched controls were prospectively investigated with H. pylori serology. Patients with ruptured AAA have similar levels of IgG antibodies against H. pylori to patients with electively operated AAA, small AAA, and controls. In conclusion, this study fails to demonstrate a connection between H. pylori CagA seropositivity and abdominal aortic aneurysm rupture.},
  author       = {Nyberg, Anders and Skagius, Elisabet and Nilsson, Ingrid and Ljungh, Åsa and Henriksson, Anders E},
  issn         = {1651-1980},
  language     = {eng},
  number       = {3},
  pages        = {204--207},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Abdominal aortic aneurysm and infection with CagA positive strains of Helicobacter pylori},
  url          = {http://dx.doi.org/10.1080/00365540701642153},
  volume       = {40},
  year         = {2008},
}