Reduction of Nystagmus as a Predictor of Efficacy of Motion Sickness Remedies
Pyykkö, I. ; Schalen, L. LU ; Magnusson, M. LU
and Matsuoka, I.
(1984)
In Advances in Psychology
22(C).
p.421-427
- Abstract
The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and dimenhydrinate reduced the vestibular gain significantly. In the optokinetic test, all drugs tended to reduce the responses, but a statistically significant reduction was found only after two TTS-scopolamine. The predictability of the efficacy of the drugs on nausea was best in the caloric test, followed by rotatory test and lowest in optokinetic... (More)
The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and dimenhydrinate reduced the vestibular gain significantly. In the optokinetic test, all drugs tended to reduce the responses, but a statistically significant reduction was found only after two TTS-scopolamine. The predictability of the efficacy of the drugs on nausea was best in the caloric test, followed by rotatory test and lowest in optokinetic test. Based on the tests about 50 per cent of the efficacy of the drugs could be predicted. The results indicate that the drugs effective against motion sickness reduce the nystagmic response, which at least partly explains the mode of action of the drugs.
(Less)
- author
- Pyykkö, I.
; Schalen, L.
LU
; Magnusson, M.
LU
and Matsuoka, I.
- publishing date
- 1984-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Advances in Psychology
- volume
- 22
- issue
- C
- pages
- 421 - 427
- publisher
- Elsevier B.V.
- external identifiers
-
- scopus:77956735067
- ISSN
- 0166-4115
- DOI
- 10.1016/S0166-4115(08)61862-2
- language
- English
- LU publication?
- no
- id
- 119479cc-094d-4d1a-a5e8-6ac3e92593e4
- date added to LUP
- 2024-07-13 22:23:24
- date last changed
- 2024-07-16 13:29:55
@article{119479cc-094d-4d1a-a5e8-6ac3e92593e4,
abstract = {{<p>The effects of transdermally administered scopolamine (TTS-scopolamine, release rate 5 g/h) and dimenhydrinate (100 pmg) were examined on caloriC., angular acceleration induced and optokinetic nystagmus in 16 volunteers in a randomized doubleblind study. All drugs induced a statistically significant decrease in maximum velocity of caloric nystagmus. In the rotatory test, two TTS-scopolamine and dimenhydrinate reduced the vestibular gain significantly. In the optokinetic test, all drugs tended to reduce the responses, but a statistically significant reduction was found only after two TTS-scopolamine. The predictability of the efficacy of the drugs on nausea was best in the caloric test, followed by rotatory test and lowest in optokinetic test. Based on the tests about 50 per cent of the efficacy of the drugs could be predicted. The results indicate that the drugs effective against motion sickness reduce the nystagmic response, which at least partly explains the mode of action of the drugs.</p>}},
author = {{Pyykkö, I. and Schalen, L. and Magnusson, M. and Matsuoka, I.}},
issn = {{0166-4115}},
language = {{eng}},
month = {{01}},
number = {{C}},
pages = {{421--427}},
publisher = {{Elsevier B.V.}},
series = {{Advances in Psychology}},
title = {{Reduction of Nystagmus as a Predictor of Efficacy of Motion Sickness Remedies}},
url = {{http://dx.doi.org/10.1016/S0166-4115(08)61862-2}},
doi = {{10.1016/S0166-4115(08)61862-2}},
volume = {{22}},
year = {{1984}},
}