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Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins.

Engström, Gunnar LU ; Borner, Gabriel; Lindblad, Bengt LU ; Janzon, Lars LU and Lindgärde, Folke LU (2004) In Arteriosclerosis, Thrombosis and Vascular Biology 24(2). p.337-341
Abstract
Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.



Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future... (More)
Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.



Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and >=3 ISPs, respectively, in the top quartile (trend: P<0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004).



Conclusion— The incidence of fatal or repaired AAA is associated with the ISP levels. In this population-based study, elevated ISPs could be observed many years before the clinical manifestation of disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, inflammation, aneurysm
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
24
issue
2
pages
337 - 341
publisher
American Heart Association
external identifiers
  • wos:000188777400020
  • pmid:14684427
  • scopus:1042279521
ISSN
1524-4636
DOI
10.1161/01.ATV.0000113292.00300.55
language
English
LU publication?
yes
id
622b26b9-10be-4ae6-8bfe-b7b9bef5ae79 (old id 119542)
date added to LUP
2007-07-18 14:23:44
date last changed
2017-09-10 03:51:34
@article{622b26b9-10be-4ae6-8bfe-b7b9bef5ae79,
  abstract     = {Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.<br/><br>
<br/><br>
Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and &gt;=3 ISPs, respectively, in the top quartile (trend: P&lt;0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004).<br/><br>
<br/><br>
Conclusion— The incidence of fatal or repaired AAA is associated with the ISP levels. In this population-based study, elevated ISPs could be observed many years before the clinical manifestation of disease.},
  author       = {Engström, Gunnar and Borner, Gabriel and Lindblad, Bengt and Janzon, Lars and Lindgärde, Folke},
  issn         = {1524-4636},
  keyword      = {epidemiology,inflammation,aneurysm},
  language     = {eng},
  number       = {2},
  pages        = {337--341},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000113292.00300.55},
  volume       = {24},
  year         = {2004},
}