Prenatal stress reduces SI00B in the neonatal rat hippocampus
(2006) In NeuroReport 17(10). p.1077-1080- Abstract
- Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of... (More)
- Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7855513
- author
- Van den Hove, Daniel L. A.
; Steinbusch, Harry W. M.
; Bruschettini, Matteo
LU
; Gazzolo, Diego ; Frulio, Rosanna ; Scheepens, Arjan ; Prickaerts, Jos and Blanco, Carlos E.
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anxiety, depression, development, pregnancy, serotonin
- in
- NeuroReport
- volume
- 17
- issue
- 10
- pages
- 1077 - 1080
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000239213000026
- scopus:33745475069
- ISSN
- 1473-558X
- DOI
- 10.1097/01.wnr.0000223391.74575.c9
- language
- English
- LU publication?
- no
- id
- 1195a05d-9419-404d-b150-983a19b22678 (old id 7855513)
- date added to LUP
- 2016-04-01 12:14:47
- date last changed
- 2025-04-04 14:00:53
@article{1195a05d-9419-404d-b150-983a19b22678, abstract = {{Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development.}}, author = {{Van den Hove, Daniel L. A. and Steinbusch, Harry W. M. and Bruschettini, Matteo and Gazzolo, Diego and Frulio, Rosanna and Scheepens, Arjan and Prickaerts, Jos and Blanco, Carlos E.}}, issn = {{1473-558X}}, keywords = {{anxiety; depression; development; pregnancy; serotonin}}, language = {{eng}}, number = {{10}}, pages = {{1077--1080}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Prenatal stress reduces SI00B in the neonatal rat hippocampus}}, url = {{http://dx.doi.org/10.1097/01.wnr.0000223391.74575.c9}}, doi = {{10.1097/01.wnr.0000223391.74575.c9}}, volume = {{17}}, year = {{2006}}, }