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Prenatal stress reduces SI00B in the neonatal rat hippocampus

Van den Hove, Daniel L. A. ; Steinbusch, Harry W. M. ; Bruschettini, Matteo LU orcid ; Gazzolo, Diego ; Frulio, Rosanna ; Scheepens, Arjan ; Prickaerts, Jos and Blanco, Carlos E. (2006) In NeuroReport 17(10). p.1077-1080
Abstract
Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of... (More)
Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development. (Less)
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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anxiety, depression, development, pregnancy, serotonin
in
NeuroReport
volume
17
issue
10
pages
1077 - 1080
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000239213000026
  • scopus:33745475069
ISSN
1473-558X
DOI
10.1097/01.wnr.0000223391.74575.c9
language
English
LU publication?
no
id
1195a05d-9419-404d-b150-983a19b22678 (old id 7855513)
date added to LUP
2016-04-01 12:14:47
date last changed
2025-04-04 14:00:53
@article{1195a05d-9419-404d-b150-983a19b22678,
  abstract     = {{Prenatal stress has been shown to disturb neonatal rat brain development. The astroglial-specific neurotrophic factor S100B is known to play an important role in normal brain development. In the present study, we investigated the effects of prenatal stress on S100B concentrations in the hippocampus of I-day-old Fischer 344 rats. Overall, prenatal stress resulted in a 25% reduction in hippocampal S100B content. Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels. Positive correlations were found between female S100B levels and fetal growth, and hippocampal brain-derived neurotrophic factor content. In conclusion, the observed reduction in neonatal hippocampal S100B levels, as a consequence of prenatal stress, may be involved in affecting postnatal brain development.}},
  author       = {{Van den Hove, Daniel L. A. and Steinbusch, Harry W. M. and Bruschettini, Matteo and Gazzolo, Diego and Frulio, Rosanna and Scheepens, Arjan and Prickaerts, Jos and Blanco, Carlos E.}},
  issn         = {{1473-558X}},
  keywords     = {{anxiety; depression; development; pregnancy; serotonin}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1077--1080}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Prenatal stress reduces SI00B in the neonatal rat hippocampus}},
  url          = {{http://dx.doi.org/10.1097/01.wnr.0000223391.74575.c9}},
  doi          = {{10.1097/01.wnr.0000223391.74575.c9}},
  volume       = {{17}},
  year         = {{2006}},
}