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Influenza A virus evolution and spatio-temporal dynamics in eurasian wild birds : A phylogenetic and phylogeographical study of whole-genome sequence data

Lewis, Nicola S.; Verhagen, Josanne H.; Javakhishvili, Zurab; Russell, Colin A.; Lexmond, Pascal; Westgeest, Kim B.; Bestebroer, Theo M.; Halpin, Rebecca A.; Lin, Xudong and Ransier, Amy, et al. (2015) In Journal of General Virology 96(8). p.2050-2060
Abstract

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian... (More)

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian IAVs from West Eurasia towards Central Eurasia. The observed viral migration patterns differed between segments. Furthermore, we discuss the challenges faced when analysing these surveillance and sequence data, and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses.

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Journal of General Virology
volume
96
issue
8
pages
11 pages
publisher
Society for General Microbiology
external identifiers
  • scopus:84938127397
ISSN
0022-1317
DOI
10.1099/vir.0.000155
language
English
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1195bf60-0994-4e63-881f-6adf787b4417
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2017-04-11 13:58:41
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2017-06-18 05:04:58
@article{1195bf60-0994-4e63-881f-6adf787b4417,
  abstract     = {<p>Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild birds. We used whole-genome sequences collected as part of an intensive long-term Eurasian wild bird surveillance study, and combined this genetic data with temporal and spatial information to explore the virus evolutionary dynamics. Frequent reassortment and co-circulating lineages were observed for all eight genomic RNA segments over time. There was no apparent species-specific effect on the diversity of the avian IAVs. There was a spatial and temporal relationship between the Eurasian sequences and significant viral migration of avian IAVs from West Eurasia towards Central Eurasia. The observed viral migration patterns differed between segments. Furthermore, we discuss the challenges faced when analysing these surveillance and sequence data, and the caveats to be borne in mind when drawing conclusions from the apparent results of such analyses.</p>},
  author       = {Lewis, Nicola S. and Verhagen, Josanne H. and Javakhishvili, Zurab and Russell, Colin A. and Lexmond, Pascal and Westgeest, Kim B. and Bestebroer, Theo M. and Halpin, Rebecca A. and Lin, Xudong and Ransier, Amy and Fedorova, Nadia B. and Stockwell, Timothy B. and Latorre-Margalef, Neus and Olsen, Björn and Smith, Gavin and Bahl, Justin and Wentworth, David E. and Waldenström, Jonas and Fouchier, Ron A. M. and de Graaf, Miranda},
  issn         = {0022-1317},
  language     = {eng},
  month        = {08},
  number       = {8},
  pages        = {2050--2060},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Influenza A virus evolution and spatio-temporal dynamics in eurasian wild birds : A phylogenetic and phylogeographical study of whole-genome sequence data},
  url          = {http://dx.doi.org/10.1099/vir.0.000155},
  volume       = {96},
  year         = {2015},
}