Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk.
(2003) In Arteriosclerosis, Thrombosis and Vascular Biology 23(12). p.2247-2251- Abstract
- Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).
Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (>=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00... (More) - Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).
Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (>=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for men with 0, 1, 2 and >=3 ISPs in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after >=10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for men with 0, 1, 2, and >=3 ISPs in the top quartile (trend: P=0.0004).
Conclusion— Incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and lipids was related to ISPs. The causes for this relationship remain to be explored. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119646
- author
- Engström, Gunnar LU ; Stavenow, Lars ; Hedblad, Bo LU ; Lind, Peter ; Tydén, Patrik LU ; Janzon, Lars LU and Lindgärde, Folke LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 23
- issue
- 12
- pages
- 2247 - 2251
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000187236600022
- pmid:14672880
- scopus:0348014416
- ISSN
- 1524-4636
- DOI
- 10.1161/01.ATV.0000102924.11767.8D
- language
- English
- LU publication?
- yes
- id
- cd0911c5-85e5-46a3-adef-2f488b042693 (old id 119646)
- date added to LUP
- 2016-04-01 12:16:14
- date last changed
- 2022-03-28 22:35:12
@article{cd0911c5-85e5-46a3-adef-2f488b042693, abstract = {{Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).<br/><br> <br/><br> Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (>=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for men with 0, 1, 2 and >=3 ISPs in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after >=10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for men with 0, 1, 2, and >=3 ISPs in the top quartile (trend: P=0.0004).<br/><br> <br/><br> Conclusion— Incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and lipids was related to ISPs. The causes for this relationship remain to be explored.}}, author = {{Engström, Gunnar and Stavenow, Lars and Hedblad, Bo and Lind, Peter and Tydén, Patrik and Janzon, Lars and Lindgärde, Folke}}, issn = {{1524-4636}}, language = {{eng}}, number = {{12}}, pages = {{2247--2251}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Arteriosclerosis, Thrombosis and Vascular Biology}}, title = {{Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk.}}, url = {{http://dx.doi.org/10.1161/01.ATV.0000102924.11767.8D}}, doi = {{10.1161/01.ATV.0000102924.11767.8D}}, volume = {{23}}, year = {{2003}}, }