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Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk.

Engström, Gunnar LU ; Stavenow, Lars; Hedblad, Bo LU ; Lind, Peter; Tydén, Patrik LU ; Janzon, Lars LU and Lindgärde, Folke LU (2003) In Arteriosclerosis, Thrombosis and Vascular Biology 23(12). p.2247-2251
Abstract
Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).



Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (>=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00... (More)
Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).



Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (>=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for men with 0, 1, 2 and >=3 ISPs in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after >=10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for men with 0, 1, 2, and >=3 ISPs in the top quartile (trend: P=0.0004).



Conclusion— Incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and lipids was related to ISPs. The causes for this relationship remain to be explored. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
23
issue
12
pages
2247 - 2251
publisher
American Heart Association
external identifiers
  • wos:000187236600022
  • pmid:14672880
  • scopus:0348014416
ISSN
1524-4636
DOI
10.1161/01.ATV.0000102924.11767.8D
language
English
LU publication?
yes
id
cd0911c5-85e5-46a3-adef-2f488b042693 (old id 119646)
date added to LUP
2007-07-18 15:37:03
date last changed
2018-05-29 09:34:46
@article{cd0911c5-85e5-46a3-adef-2f488b042693,
  abstract     = {Objective— Myocardial infarction (MI) is sometimes experienced by individuals without any traditional risk factor. This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs).<br/><br>
<br/><br>
Methods and Results— Five ISPs ({alpha}1-antitrypsin, haptoglobin, ceruloplasmin, fibrinogen, orosomucoid) were analyzed in 6075 men, 47±3.6 years old. A low-risk group (no traditional risk factor, n=1108) and a high-risk group (&gt;=2 major risk factors, n=1011) were defined. Incidence of MI (n=227) was monitored over 18.1±4.3 years of follow-up. In the low-risk group, the age-adjusted relative risks (RRs) were 1.00 (reference), 1.9 (95% CI, 0.8 to 4.2), 1.8 (95% CI, 0.6 to 5.4), and 2.9 (95% CI, 1.05 to 8.1), respectively, for men with 0, 1, 2 and &gt;=3 ISPs in the top quartile (trend: P=0.03). In this group, the increased risk was observed only after &gt;=10 years of follow-up. In the high-risk group, the age-adjusted RRs were 1.00, 1.4 (95% CI, 0.9 to 2.2), 1.9 (95% CI, 1.2 to 3.1), and 2.0 (95% CI, 1.3 to 3.1), respectively, for men with 0, 1, 2, and &gt;=3 ISPs in the top quartile (trend: P=0.0004).<br/><br>
<br/><br>
Conclusion— Incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and lipids was related to ISPs. The causes for this relationship remain to be explored.},
  author       = {Engström, Gunnar and Stavenow, Lars and Hedblad, Bo and Lind, Peter and Tydén, Patrik and Janzon, Lars and Lindgärde, Folke},
  issn         = {1524-4636},
  language     = {eng},
  number       = {12},
  pages        = {2247--2251},
  publisher    = {American Heart Association},
  series       = {Arteriosclerosis, Thrombosis and Vascular Biology},
  title        = {Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk.},
  url          = {http://dx.doi.org/10.1161/01.ATV.0000102924.11767.8D},
  volume       = {23},
  year         = {2003},
}