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Thermodynamics and kinetics of a Go(o)over-bar proteinlike heteropolymer model with two-state folding characteristics

Kallias, Anna; Bachmann, Michael LU and Janke, Wolfhard (2008) In Journal of Chemical Physics 128(5). p.7-055102
Abstract
We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar G (o) over bar -like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chemical Physics
volume
128
issue
5
pages
7 - 055102
publisher
American Institute of Physics
external identifiers
  • wos:000253125700059
  • scopus:41449107942
ISSN
0021-9606
DOI
10.1063/1.2822287
language
English
LU publication?
yes
id
e3e3aec3-eba0-4f64-9b8b-45d64ade175b (old id 1196504)
date added to LUP
2008-09-10 11:41:24
date last changed
2017-08-06 03:31:14
@article{e3e3aec3-eba0-4f64-9b8b-45d64ade175b,
  abstract     = {We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar G (o) over bar -like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.},
  author       = {Kallias, Anna and Bachmann, Michael and Janke, Wolfhard},
  issn         = {0021-9606},
  language     = {eng},
  number       = {5},
  pages        = {7--055102},
  publisher    = {American Institute of Physics},
  series       = {Journal of Chemical Physics},
  title        = {Thermodynamics and kinetics of a Go(o)over-bar proteinlike heteropolymer model with two-state folding characteristics},
  url          = {http://dx.doi.org/10.1063/1.2822287},
  volume       = {128},
  year         = {2008},
}