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Thermodynamics and kinetics of a Go(o)over-bar proteinlike heteropolymer model with two-state folding characteristics

Kallias, Anna ; Bachmann, Michael LU and Janke, Wolfhard (2008) In Journal of Chemical Physics 128(5). p.7-055102
Abstract
We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar G (o) over bar -like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chemical Physics
volume
128
issue
5
pages
7 - 055102
publisher
American Institute of Physics (AIP)
external identifiers
  • wos:000253125700059
  • scopus:41449107942
ISSN
0021-9606
DOI
10.1063/1.2822287
language
English
LU publication?
yes
id
e3e3aec3-eba0-4f64-9b8b-45d64ade175b (old id 1196504)
date added to LUP
2016-04-01 11:38:34
date last changed
2024-01-07 14:59:42
@article{e3e3aec3-eba0-4f64-9b8b-45d64ade175b,
  abstract     = {{We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar G (o) over bar -like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.}},
  author       = {{Kallias, Anna and Bachmann, Michael and Janke, Wolfhard}},
  issn         = {{0021-9606}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{7--055102}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{Journal of Chemical Physics}},
  title        = {{Thermodynamics and kinetics of a Go(o)over-bar proteinlike heteropolymer model with two-state folding characteristics}},
  url          = {{http://dx.doi.org/10.1063/1.2822287}},
  doi          = {{10.1063/1.2822287}},
  volume       = {{128}},
  year         = {{2008}},
}