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Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding

Kuchinskaya, Ekaterina; Heyman, Mats; Nordgren, Ann; Schoumans, Jacqueline; Staaf, Johan LU ; Borg, Åke LU ; Söderhäll, Stefan; Grander, Dan; Nordenskjöld, Magnus and Blennow, Elisabeth (2008) In British Journal of Haematology 140(5). p.572-577
Abstract
A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tiling-resolution array-comparative genomic hybridization, childhood acute lymphoblastic leukaemia, normal karyotype
in
British Journal of Haematology
volume
140
issue
5
pages
572 - 577
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000253041400012
  • scopus:38949187918
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2007.06917.x
language
English
LU publication?
yes
id
119c3b4b-a26e-410c-9907-7566f2dcbda3 (old id 1198803)
date added to LUP
2008-09-10 17:07:45
date last changed
2017-01-01 05:10:25
@article{119c3b4b-a26e-410c-9907-7566f2dcbda3,
  abstract     = {A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.},
  author       = {Kuchinskaya, Ekaterina and Heyman, Mats and Nordgren, Ann and Schoumans, Jacqueline and Staaf, Johan and Borg, Åke and Söderhäll, Stefan and Grander, Dan and Nordenskjöld, Magnus and Blennow, Elisabeth},
  issn         = {0007-1048},
  keyword      = {tiling-resolution array-comparative genomic hybridization,childhood acute lymphoblastic leukaemia,normal karyotype},
  language     = {eng},
  number       = {5},
  pages        = {572--577},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2007.06917.x},
  volume       = {140},
  year         = {2008},
}