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Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data

Broman, Aimee Teo; Quigley, Harry A.; West, Sheila K.; Katz, Joanne; Munoz, Beatriz; Bandeen-Roche, Karen; Tielsch, James M.; Friedman, David S.; Crowston, Jonathan and Taylor, Hugh R., et al. (2008) In Investigative Ophthalmology & Visual Science 49(1). p.66-76
Abstract
PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects... (More)
PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95% CI: 8.8-12.6) and was highest in African-derived subjects at 15.4 years (95% CI: 14.6-15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15% or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects. (Less)
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Investigative Ophthalmology & Visual Science
volume
49
issue
1
pages
66 - 76
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • wos:000252747000010
  • scopus:39549106321
ISSN
1552-5783
DOI
10.1167/iovs.07-0866
language
English
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yes
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901251c0-cc33-48ed-b2bc-b49c9a263e4a (old id 1199074)
date added to LUP
2008-09-11 09:46:30
date last changed
2017-08-13 03:55:38
@article{901251c0-cc33-48ed-b2bc-b49c9a263e4a,
  abstract     = {PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG damage was the mean deviation (MD) of an automated visual field test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). The rate of progression was the mean of all subjects' damage in the worse eye divided by an average time since onset. Time since onset was estimated from age-specific prevalence rates. RESULTS. A total of 1066 subjects with OAG contributed visual field data. The mean worsening in decibels per year was: European-derived, -1.12; Hispanic, -1.26; African-derived, -1.33; and Chinese -1.56 (difference among ethnicities, P = 0.16). The mean duration of disease was lowest among Chinese persons at 10.5 years (95% CI: 8.8-12.6) and was highest in African-derived subjects at 15.4 years (95% CI: 14.6-15.9). The progression rate was not consistently related to age or gender. By combining disease duration and progression rate, the model predicted that 15% or fewer of the worse eyes would reach the end of the field damage scale in the patient's lifetime. CONCLUSIONS. The estimates of typical worsening per year in the worse eye among subjects with OAG suggested slightly more rapid progression than in some clinic-based studies. The rate did not differ significantly by ethnicity or gender, but was worse in those with known, treated OAG and in pseudophakic subjects.},
  author       = {Broman, Aimee Teo and Quigley, Harry A. and West, Sheila K. and Katz, Joanne and Munoz, Beatriz and Bandeen-Roche, Karen and Tielsch, James M. and Friedman, David S. and Crowston, Jonathan and Taylor, Hugh R. and Varma, Rohit and Leske, M. Cristina and Bengtsson, Boel and Heijl, Anders and He, Mingguang and Foster, Paul J.},
  issn         = {1552-5783},
  language     = {eng},
  number       = {1},
  pages        = {66--76},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data},
  url          = {http://dx.doi.org/10.1167/iovs.07-0866},
  volume       = {49},
  year         = {2008},
}