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Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent

Perez, Paloma; Plieva, Fatima LU ; Gallardo, Alberto; Roman, Julio San; Aguilar, Maria Rosa; Morfin, Isabelle; Ehrburger-Dolle, Frangoise; Bley, Francoise; Mikhalovsky, Sergey and Galaev, Igor LU , et al. (2008) In Biomacromolecules 9(1). p.66-74
Abstract
Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacryliccompounds, N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT crosslinked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA,... (More)
Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacryliccompounds, N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT crosslinked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA, was over ten times higher than that of the gels synthesized at room temperature from the same feed composition. The MBAAm cross-linked pNIPA cryogels synthesized in water exhibited the highest equilibrium swelling and the fastest response. The critical transition temperature, T-c, was lower (T-c approximate to 31 degrees C) for pNIPA-cryogels synthesized in dioxane/water media or cross-linked with DMTLT as compared to MBAAm cross-linked pNIPA cryogels synthesized in water (T-c approximate to 33 degrees C). Scanning electron microscopy (SEM) revealed different porous structure and pore surface morphology depending on the cross-linker (MBAAm or DMTLT) and the solvent (water or dioxane/water) used. Gels and cryogels were also characterized by SAXS, showing that the nanostructure of the samples is related to swelling. (Less)
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type
Contribution to journal
publication status
published
subject
in
Biomacromolecules
volume
9
issue
1
pages
66 - 74
publisher
The American Chemical Society
external identifiers
  • wos:000252415600011
  • scopus:38849204179
ISSN
1526-4602
DOI
10.1021/bm7007668
language
English
LU publication?
yes
id
1a09f846-f26e-4ba1-8a31-e89474c69c62 (old id 1199971)
date added to LUP
2008-09-11 14:14:11
date last changed
2017-07-23 03:42:03
@article{1a09f846-f26e-4ba1-8a31-e89474c69c62,
  abstract     = {Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacryliccompounds, N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT crosslinked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA, was over ten times higher than that of the gels synthesized at room temperature from the same feed composition. The MBAAm cross-linked pNIPA cryogels synthesized in water exhibited the highest equilibrium swelling and the fastest response. The critical transition temperature, T-c, was lower (T-c approximate to 31 degrees C) for pNIPA-cryogels synthesized in dioxane/water media or cross-linked with DMTLT as compared to MBAAm cross-linked pNIPA cryogels synthesized in water (T-c approximate to 33 degrees C). Scanning electron microscopy (SEM) revealed different porous structure and pore surface morphology depending on the cross-linker (MBAAm or DMTLT) and the solvent (water or dioxane/water) used. Gels and cryogels were also characterized by SAXS, showing that the nanostructure of the samples is related to swelling.},
  author       = {Perez, Paloma and Plieva, Fatima and Gallardo, Alberto and Roman, Julio San and Aguilar, Maria Rosa and Morfin, Isabelle and Ehrburger-Dolle, Frangoise and Bley, Francoise and Mikhalovsky, Sergey and Galaev, Igor and Mattiasson, Bo},
  issn         = {1526-4602},
  language     = {eng},
  number       = {1},
  pages        = {66--74},
  publisher    = {The American Chemical Society},
  series       = {Biomacromolecules},
  title        = {Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent},
  url          = {http://dx.doi.org/10.1021/bm7007668},
  volume       = {9},
  year         = {2008},
}