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Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding

Kuchinskaya, Ekaterina ; Heyman, Mats ; Nordgren, Ann ; Schoumans, Jacqueline ; Staaf, Johan LU orcid ; Borg, Åke LU ; Söderhäll, Stefan ; Grander, Dan ; Nordenskjöld, Magnus and Blennow, Elisabeth (2008) In British Journal of Haematology 140(5). p.572-577
Abstract
A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tiling-resolution array-comparative genomic hybridization, childhood acute lymphoblastic leukaemia, normal karyotype
in
British Journal of Haematology
volume
140
issue
5
pages
572 - 577
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000253041400012
  • scopus:38949187918
  • pmid:18275435
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2007.06917.x
language
English
LU publication?
yes
id
119c3b4b-a26e-410c-9907-7566f2dcbda3 (old id 1198803)
date added to LUP
2016-04-01 12:28:22
date last changed
2025-10-14 09:27:20
@article{119c3b4b-a26e-410c-9907-7566f2dcbda3,
  abstract     = {{A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.}},
  author       = {{Kuchinskaya, Ekaterina and Heyman, Mats and Nordgren, Ann and Schoumans, Jacqueline and Staaf, Johan and Borg, Åke and Söderhäll, Stefan and Grander, Dan and Nordenskjöld, Magnus and Blennow, Elisabeth}},
  issn         = {{0007-1048}},
  keywords     = {{tiling-resolution array-comparative genomic hybridization; childhood acute lymphoblastic leukaemia; normal karyotype}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{572--577}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{British Journal of Haematology}},
  title        = {{Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2141.2007.06917.x}},
  doi          = {{10.1111/j.1365-2141.2007.06917.x}},
  volume       = {{140}},
  year         = {{2008}},
}