PAP treatment in patients with OSA does not induce long-term nasal obstruction
(2019) In Journal of Sleep Research 28(5).- Abstract
We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small... (More)
We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small interior nasal dimensions increased (p < 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction.
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- author
- Värendh, Maria LU ; Andersson, Morgan LU ; Björnsdóttir, Erla ; Arnardóttir, Erna S. ; Gislason, Thorarinn ; Pack, Allan I. ; Hrubos-Strøm, Harald ; Johannisson, Arne LU and Juliusson, Sigurdur
- organization
- publishing date
- 2019-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acoustic measurements, adherence, apnea, breathing, nasal anatomy, nose, survey
- in
- Journal of Sleep Research
- volume
- 28
- issue
- 5
- article number
- e12768
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85053929012
- pmid:30264448
- ISSN
- 0962-1105
- DOI
- 10.1111/jsr.12768
- language
- English
- LU publication?
- yes
- id
- 11bb0800-64f7-409f-a6d1-8097d5b93329
- date added to LUP
- 2018-10-26 08:23:45
- date last changed
- 2024-07-08 22:23:44
@article{11bb0800-64f7-409f-a6d1-8097d5b93329,
abstract = {{<p>We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small interior nasal dimensions increased (p < 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction.</p>}},
author = {{Värendh, Maria and Andersson, Morgan and Björnsdóttir, Erla and Arnardóttir, Erna S. and Gislason, Thorarinn and Pack, Allan I. and Hrubos-Strøm, Harald and Johannisson, Arne and Juliusson, Sigurdur}},
issn = {{0962-1105}},
keywords = {{acoustic measurements; adherence; apnea; breathing; nasal anatomy; nose; survey}},
language = {{eng}},
number = {{5}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Sleep Research}},
title = {{PAP treatment in patients with OSA does not induce long-term nasal obstruction}},
url = {{http://dx.doi.org/10.1111/jsr.12768}},
doi = {{10.1111/jsr.12768}},
volume = {{28}},
year = {{2019}},
}