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PAP treatment in patients with OSA does not induce long-term nasal obstruction

Värendh, Maria LU ; Andersson, Morgan LU ; Björnsdóttir, Erla; Arnardóttir, Erna S.; Gislason, Thorarinn; Pack, Allan I.; Hrubos-Strøm, Harald; Johannisson, Arne LU and Juliusson, Sigurdur (2018) In Journal of Sleep Research
Abstract

We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small... (More)

We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p < 0.001). Small interior nasal dimensions increased (p < 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
acoustic measurements, adherence, apnea, breathing, nasal anatomy, nose, survey
in
Journal of Sleep Research
publisher
Wiley-Blackwell
external identifiers
  • scopus:85053929012
ISSN
0962-1105
DOI
10.1111/jsr.12768
language
English
LU publication?
yes
id
11bb0800-64f7-409f-a6d1-8097d5b93329
date added to LUP
2018-10-26 08:23:45
date last changed
2019-02-20 11:33:26
@article{11bb0800-64f7-409f-a6d1-8097d5b93329,
  abstract     = {<p>We hypothesized that positive airway pressure treatment would induce nasal obstruction and decrease nasal cavity due to mucosal swelling. We further hypothesized that subjective and objective nasal obstruction at baseline would negatively affect positive airway pressure adherence. A total of 728 patients with sleep apnea were investigated in the Icelandic Sleep Apnea Cohort at baseline and 2 years after starting positive airway pressure. Patients underwent home sleep apnea testing at baseline. Questionnaires were answered and acoustic rhinometry was completed at baseline and follow-up. The proportion of patients reporting subjective nocturnal nasal obstruction was reduced (baseline: 35% versus follow-up: 24%; p &lt; 0.001). Small interior nasal dimensions increased (p &lt; 0.001) independent of adherence to treatment. Small nasal volume at baseline was a determinant for becoming a non-user of positive airway pressure treatment (odds ratio 2.22, confidence interval 95% 1.35–3.67, p = 0.002). Subjective nasal obstruction decreased 2 years after initiating positive airway treatment in sleep apnea, and objectively small nasal dimensions increased. Small nasal volume at baseline was a negative predictor for positive airway pressure treatment adherence. Maybe most importantly, positive airway pressure treatment did not cause long-term objective or subjective nasal obstruction.</p>},
  articleno    = {e12768},
  author       = {Värendh, Maria and Andersson, Morgan and Björnsdóttir, Erla and Arnardóttir, Erna S. and Gislason, Thorarinn and Pack, Allan I. and Hrubos-Strøm, Harald and Johannisson, Arne and Juliusson, Sigurdur},
  issn         = {0962-1105},
  keyword      = {acoustic measurements,adherence,apnea,breathing,nasal anatomy,nose,survey},
  language     = {eng},
  month        = {09},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Sleep Research},
  title        = {PAP treatment in patients with OSA does not induce long-term nasal obstruction},
  url          = {http://dx.doi.org/10.1111/jsr.12768},
  year         = {2018},
}