Advanced

Optimising islet engraftment is critical for successful clinical islet transplantation

Korsgren, O; Lundgren, T; Felldin, M; Foss, A; Isaksson, B; Permert, J; Persson, N H LU ; Rafael, E; Ryden, M and Salmela, K, et al. (2008) In Diabetologia 51(2). p.227-232
Abstract
Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tumour metastasis, revascularisation, thrombosis, liver morphology, islet transplantation, intramuscular, intraportal, innate immunity, clinical, engraftment
in
Diabetologia
volume
51
issue
2
pages
227 - 232
publisher
Springer Verlag
external identifiers
  • wos:000251995200004
  • scopus:37549056921
ISSN
1432-0428
DOI
10.1007/s00125-007-0868-9
language
English
LU publication?
yes
id
34a8b20b-9142-4ba2-97cf-ea76c95312e7 (old id 1200293)
date added to LUP
2008-09-12 12:11:52
date last changed
2017-10-22 03:47:17
@article{34a8b20b-9142-4ba2-97cf-ea76c95312e7,
  abstract     = {Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.},
  author       = {Korsgren, O and Lundgren, T and Felldin, M and Foss, A and Isaksson, B and Permert, J and Persson, N H and Rafael, E and Ryden, M and Salmela, K and Tibell, A and Tufveson, G and Nilsson, B},
  issn         = {1432-0428},
  keyword      = {tumour metastasis,revascularisation,thrombosis,liver morphology,islet transplantation,intramuscular,intraportal,innate immunity,clinical,engraftment},
  language     = {eng},
  number       = {2},
  pages        = {227--232},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Optimising islet engraftment is critical for successful clinical islet transplantation},
  url          = {http://dx.doi.org/10.1007/s00125-007-0868-9},
  volume       = {51},
  year         = {2008},
}