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Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats

Marcussen, A B; Flagstad, P; Kristjansen, P E G; Johansen, F F and Englund Johansson, Ulrica LU (2008) In Acta Neurologica Scandinavica 117(2). p.94-100
Abstract
Objective - Disturbances in hippocampal neurogenesis may be involved in the pathophysiology of depression and it has been argued that an increase in the generation of new nerve cells in the hippocampus is involved in the mechanism of action of antidepressants. Materials and Methods - Adult Wistar rats were treated with fluoxetine (10 mg/kg) 1 h, daily for 5 (subchronic) or 28 days (chronic) before the Novelty Suppressed Feeding test was performed. Cell proliferation and neurogenesis were analysed using the markers 5-bromo-deoxy-2'-uridine, Ki-67, and doublecortin. Results - A significant behavioural effect was found after 28 days of fluoxetine administration. However, no behavioural improvement was demonstrated after acute and subchronic... (More)
Objective - Disturbances in hippocampal neurogenesis may be involved in the pathophysiology of depression and it has been argued that an increase in the generation of new nerve cells in the hippocampus is involved in the mechanism of action of antidepressants. Materials and Methods - Adult Wistar rats were treated with fluoxetine (10 mg/kg) 1 h, daily for 5 (subchronic) or 28 days (chronic) before the Novelty Suppressed Feeding test was performed. Cell proliferation and neurogenesis were analysed using the markers 5-bromo-deoxy-2'-uridine, Ki-67, and doublecortin. Results - A significant behavioural effect was found after 28 days of fluoxetine administration. However, no behavioural improvement was demonstrated after acute and subchronic treatment with fluoxetine. We further demonstrate that chronic antidepressant treatment increases cell proliferation as well as neurogenesis in the dentate gyrus, here using Wistar rats. Conclusions - In further development of antidepressants, neurogenesis may serve as an important parameter to examine the efficacy and mechanism of action of novel drugs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hippocampus, behaviour, antidepressants, cell proliferation, neurogenesis
in
Acta Neurologica Scandinavica
volume
117
issue
2
pages
94 - 100
publisher
Wiley-Blackwell
external identifiers
  • wos:000252119600004
  • scopus:37849034986
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2007.00910.x
language
English
LU publication?
yes
id
787e1b2a-1ce1-4568-954c-3f018cc3fdfe (old id 1200331)
date added to LUP
2008-09-12 12:25:05
date last changed
2017-11-12 03:42:54
@article{787e1b2a-1ce1-4568-954c-3f018cc3fdfe,
  abstract     = {Objective - Disturbances in hippocampal neurogenesis may be involved in the pathophysiology of depression and it has been argued that an increase in the generation of new nerve cells in the hippocampus is involved in the mechanism of action of antidepressants. Materials and Methods - Adult Wistar rats were treated with fluoxetine (10 mg/kg) 1 h, daily for 5 (subchronic) or 28 days (chronic) before the Novelty Suppressed Feeding test was performed. Cell proliferation and neurogenesis were analysed using the markers 5-bromo-deoxy-2'-uridine, Ki-67, and doublecortin. Results - A significant behavioural effect was found after 28 days of fluoxetine administration. However, no behavioural improvement was demonstrated after acute and subchronic treatment with fluoxetine. We further demonstrate that chronic antidepressant treatment increases cell proliferation as well as neurogenesis in the dentate gyrus, here using Wistar rats. Conclusions - In further development of antidepressants, neurogenesis may serve as an important parameter to examine the efficacy and mechanism of action of novel drugs.},
  author       = {Marcussen, A B and Flagstad, P and Kristjansen, P E G and Johansen, F F and Englund Johansson, Ulrica},
  issn         = {1600-0404},
  keyword      = {hippocampus,behaviour,antidepressants,cell proliferation,neurogenesis},
  language     = {eng},
  number       = {2},
  pages        = {94--100},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Neurologica Scandinavica},
  title        = {Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2007.00910.x},
  volume       = {117},
  year         = {2008},
}