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Endocrinological late complications after hematopoietic SCT in children

Cohen, A; Békássy, Albert LU ; Gaiero, A; Faraci, M; Zecca, S; Tichelli, A and Dini, G (2008) In Bone Marrow Transplantation 41. p.43-48
Abstract
The main challenge for a pediatric hemato-oncologist today is to obtain a cure for the sick child with the minimum of treatment-related complications. Children on their way to achieving adulthood face many risks after hematopoietic SCT (HSCT). Continuous follow-up includes assessment of organ function, focus on vaccinations and screening for secondary malignancies. Updated treatment protocols are already adjusted according to the knowledge obtained on late effects, and the potential risks for complications are well balanced with expected benefits hopefully resulting in decreased potential risk for organ damage but still maintaining an unchanged or improved survival rate. Recent developments on pre-HSCT regimens, such as the introduction of... (More)
The main challenge for a pediatric hemato-oncologist today is to obtain a cure for the sick child with the minimum of treatment-related complications. Children on their way to achieving adulthood face many risks after hematopoietic SCT (HSCT). Continuous follow-up includes assessment of organ function, focus on vaccinations and screening for secondary malignancies. Updated treatment protocols are already adjusted according to the knowledge obtained on late effects, and the potential risks for complications are well balanced with expected benefits hopefully resulting in decreased potential risk for organ damage but still maintaining an unchanged or improved survival rate. Recent developments on pre-HSCT regimens, such as the introduction of new anticancer regimens and immunosuppressive agents will hopefully contribute to minimize the frequency and the severity of late complications. Knowledge about increased risk for long-term complications due to cancer therapy and pre-HSCT preparative regimens should encourage each caring physician to stick to follow-up protocols and treatment guidelines not only to improve the survival rate of transplanted children but also to improve their quality of life. To achieve adulthood by maintaining cognitive ability and psychosocial skills is the highest goal for an individual to become a competent member of a society. This review of late endocrine complications after HSCT focuses on growth, pubertal development, thyroid disorders and glucose metabolism in long-term survivors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SCT, thyroid, puberty, growth, endocrine system, late complications
in
Bone Marrow Transplantation
volume
41
pages
43 - 48
publisher
Nature Publishing Group
external identifiers
  • wos:000256660100011
  • scopus:45749091856
ISSN
1476-5365
DOI
10.1038/bmt.2008.54
language
English
LU publication?
yes
id
7ff469ce-a207-43dd-b4da-842ccc9a32b9 (old id 1200347)
date added to LUP
2008-09-12 12:40:03
date last changed
2017-09-10 03:42:46
@article{7ff469ce-a207-43dd-b4da-842ccc9a32b9,
  abstract     = {The main challenge for a pediatric hemato-oncologist today is to obtain a cure for the sick child with the minimum of treatment-related complications. Children on their way to achieving adulthood face many risks after hematopoietic SCT (HSCT). Continuous follow-up includes assessment of organ function, focus on vaccinations and screening for secondary malignancies. Updated treatment protocols are already adjusted according to the knowledge obtained on late effects, and the potential risks for complications are well balanced with expected benefits hopefully resulting in decreased potential risk for organ damage but still maintaining an unchanged or improved survival rate. Recent developments on pre-HSCT regimens, such as the introduction of new anticancer regimens and immunosuppressive agents will hopefully contribute to minimize the frequency and the severity of late complications. Knowledge about increased risk for long-term complications due to cancer therapy and pre-HSCT preparative regimens should encourage each caring physician to stick to follow-up protocols and treatment guidelines not only to improve the survival rate of transplanted children but also to improve their quality of life. To achieve adulthood by maintaining cognitive ability and psychosocial skills is the highest goal for an individual to become a competent member of a society. This review of late endocrine complications after HSCT focuses on growth, pubertal development, thyroid disorders and glucose metabolism in long-term survivors.},
  author       = {Cohen, A and Békássy, Albert and Gaiero, A and Faraci, M and Zecca, S and Tichelli, A and Dini, G},
  issn         = {1476-5365},
  keyword      = {SCT,thyroid,puberty,growth,endocrine system,late complications},
  language     = {eng},
  pages        = {43--48},
  publisher    = {Nature Publishing Group},
  series       = {Bone Marrow Transplantation},
  title        = {Endocrinological late complications after hematopoietic SCT in children},
  url          = {http://dx.doi.org/10.1038/bmt.2008.54},
  volume       = {41},
  year         = {2008},
}