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Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy

Knowles, C H; Veress, Bela LU ; Tornblom, H; Wallace, S; Paraskeva, P; Darzi, A; Martin, J E; Nyberg, B and Lindberg, G (2008) In Neurogastroenterology and Motility 20(7). p.774-779
Abstract
Advances in minimally invasive surgery have made laparoscopy and full-thickness bowel biopsy possible in the investigation of patients with suspected gastrointestinal neuromuscular disorders. The safety and diagnostic yield of this investigation have not been formally reported. A prospective study was undertaken of 124 patients with clinico-physiological diagnoses of chronic intestinal pseudo-obstruction, enteric dysmotility and severe irritable bowel syndrome undergoing LFTB in three European teaching centres with expertise in the management of gastrointestinal neuromuscular disorders. Perioperative data were collected including complications. Diagnostic yield was expressed as proportion with well-established specific neuromuscular... (More)
Advances in minimally invasive surgery have made laparoscopy and full-thickness bowel biopsy possible in the investigation of patients with suspected gastrointestinal neuromuscular disorders. The safety and diagnostic yield of this investigation have not been formally reported. A prospective study was undertaken of 124 patients with clinico-physiological diagnoses of chronic intestinal pseudo-obstruction, enteric dysmotility and severe irritable bowel syndrome undergoing LFTB in three European teaching centres with expertise in the management of gastrointestinal neuromuscular disorders. Perioperative data were collected including complications. Diagnostic yield was expressed as proportion with well-established specific neuromuscular abnormalities based on a protocol of routine and immunohistochemical techniques. The majority of patients underwent a laparoscopically assisted procedure with extracorporeal biopsy. Median operating time was 50 min, conversion rate 2% and length of stay 1 day. There was an 8% readmission rate for obstructive symptoms but minimal other morbidity and no mortality. Overall specific diagnostic yield was 81%, being high for jejunal biopsies (89%) but low for a small number of ileal and colonic biopsies. Laparoscopy and full-thickness biopsy of the bowel appears acceptable in terms of safety. It should be performed in a jejunal site to achieve a high diagnostic yield. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
laparoscopic biopsy, intestinal pseudo-obstruction, enteric myopathy, enteric neuropathy
in
Neurogastroenterology and Motility
volume
20
issue
7
pages
774 - 779
publisher
Wiley-Blackwell
external identifiers
  • wos:000256636600006
  • scopus:44949212706
ISSN
1350-1925
DOI
10.1111/j.1365-2982.2008.01099.x
language
English
LU publication?
yes
id
02cf5aed-e382-4b9c-a46f-20bd452f99ee (old id 1201144)
date added to LUP
2008-09-12 15:21:37
date last changed
2017-01-08 04:14:51
@article{02cf5aed-e382-4b9c-a46f-20bd452f99ee,
  abstract     = {Advances in minimally invasive surgery have made laparoscopy and full-thickness bowel biopsy possible in the investigation of patients with suspected gastrointestinal neuromuscular disorders. The safety and diagnostic yield of this investigation have not been formally reported. A prospective study was undertaken of 124 patients with clinico-physiological diagnoses of chronic intestinal pseudo-obstruction, enteric dysmotility and severe irritable bowel syndrome undergoing LFTB in three European teaching centres with expertise in the management of gastrointestinal neuromuscular disorders. Perioperative data were collected including complications. Diagnostic yield was expressed as proportion with well-established specific neuromuscular abnormalities based on a protocol of routine and immunohistochemical techniques. The majority of patients underwent a laparoscopically assisted procedure with extracorporeal biopsy. Median operating time was 50 min, conversion rate 2% and length of stay 1 day. There was an 8% readmission rate for obstructive symptoms but minimal other morbidity and no mortality. Overall specific diagnostic yield was 81%, being high for jejunal biopsies (89%) but low for a small number of ileal and colonic biopsies. Laparoscopy and full-thickness biopsy of the bowel appears acceptable in terms of safety. It should be performed in a jejunal site to achieve a high diagnostic yield.},
  author       = {Knowles, C H and Veress, Bela and Tornblom, H and Wallace, S and Paraskeva, P and Darzi, A and Martin, J E and Nyberg, B and Lindberg, G},
  issn         = {1350-1925},
  keyword      = {laparoscopic biopsy,intestinal pseudo-obstruction,enteric myopathy,enteric neuropathy},
  language     = {eng},
  number       = {7},
  pages        = {774--779},
  publisher    = {Wiley-Blackwell},
  series       = {Neurogastroenterology and Motility},
  title        = {Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy},
  url          = {http://dx.doi.org/10.1111/j.1365-2982.2008.01099.x},
  volume       = {20},
  year         = {2008},
}