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Early amplitude-integrated EEG correlates with cord TNF-alpha and brain injury in very preterm infants

Wikstrom, Sverre; Ley, David LU ; Pupp, Ingrid LU ; Rosén, Ingmar LU and Hellstrom-Westas, Lena (2008) In Acta Pædiatrica 97(7). p.915-919
Abstract
Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results:... (More)
Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results: Infants with neonatal brain injury (n = 9) had prolonged IBI, 11.8 (9.6-23.2) sec versus 8.2 (7.1-11.6) sec in infants (n = 7) without brain damage (p = 0.005). Handicap at 2 years (n = 8, including two infants without neonatally diagnosed brain injury) was associated with prolonged neonatal IBI and lower aEEG amplitudes. Also aEEG amplitudes were decreased in infants with neonatal brain injury. There was a significant positive correlation between the averaged IBI and cord blood TNF-alpha (rs = 0.595, p = 0.025). Conclusion: Early EEG depression is associated with increased cord blood TNF-alpha, neonatal brain damage and handicap at 2 years. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prognosis, preterm, cytokines, aEEG, brain injury
in
Acta Pædiatrica
volume
97
issue
7
pages
915 - 919
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000256395300021
  • scopus:44849086085
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.00787.x
language
English
LU publication?
yes
id
71c289f8-1e79-46ba-ba79-14a27f93fa6f (old id 1201533)
date added to LUP
2008-09-15 10:55:01
date last changed
2017-11-19 03:41:17
@article{71c289f8-1e79-46ba-ba79-14a27f93fa6f,
  abstract     = {Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results: Infants with neonatal brain injury (n = 9) had prolonged IBI, 11.8 (9.6-23.2) sec versus 8.2 (7.1-11.6) sec in infants (n = 7) without brain damage (p = 0.005). Handicap at 2 years (n = 8, including two infants without neonatally diagnosed brain injury) was associated with prolonged neonatal IBI and lower aEEG amplitudes. Also aEEG amplitudes were decreased in infants with neonatal brain injury. There was a significant positive correlation between the averaged IBI and cord blood TNF-alpha (rs = 0.595, p = 0.025). Conclusion: Early EEG depression is associated with increased cord blood TNF-alpha, neonatal brain damage and handicap at 2 years.},
  author       = {Wikstrom, Sverre and Ley, David and Pupp, Ingrid and Rosén, Ingmar and Hellstrom-Westas, Lena},
  issn         = {1651-2227},
  keyword      = {prognosis,preterm,cytokines,aEEG,brain injury},
  language     = {eng},
  number       = {7},
  pages        = {915--919},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Early amplitude-integrated EEG correlates with cord TNF-alpha and brain injury in very preterm infants},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2008.00787.x},
  volume       = {97},
  year         = {2008},
}