Early amplitude-integrated EEG correlates with cord TNF-alpha and brain injury in very preterm infants
Wikstrom, Sverre ; Ley, David LU ; Pupp, Ingrid LU
; Rosén, Ingmar
LU
and Hellstrom-Westas, Lena
(2008)
In Acta Pædiatrica
97(7).
p.915-919
- Abstract
- Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results:... (More)
- Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results: Infants with neonatal brain injury (n = 9) had prolonged IBI, 11.8 (9.6-23.2) sec versus 8.2 (7.1-11.6) sec in infants (n = 7) without brain damage (p = 0.005). Handicap at 2 years (n = 8, including two infants without neonatally diagnosed brain injury) was associated with prolonged neonatal IBI and lower aEEG amplitudes. Also aEEG amplitudes were decreased in infants with neonatal brain injury. There was a significant positive correlation between the averaged IBI and cord blood TNF-alpha (rs = 0.595, p = 0.025). Conclusion: Early EEG depression is associated with increased cord blood TNF-alpha, neonatal brain damage and handicap at 2 years. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1201533
- author
- Wikstrom, Sverre
; Ley, David
LU
; Pupp, Ingrid
LU
; Rosén, Ingmar
LU
and Hellstrom-Westas, Lena
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prognosis, preterm, cytokines, aEEG, brain injury
- in
- Acta Pædiatrica
- volume
- 97
- issue
- 7
- pages
- 915 - 919
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000256395300021
- scopus:44849086085
- pmid:18462469
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2008.00787.x
- language
- English
- LU publication?
- yes
- id
- 71c289f8-1e79-46ba-ba79-14a27f93fa6f (old id 1201533)
- date added to LUP
- 2016-04-01 12:54:20
- date last changed
- 2023-09-02 15:48:19
@article{71c289f8-1e79-46ba-ba79-14a27f93fa6f,
abstract = {{Aim: To investigate if the early electroencephalogram (EEG) and amplitude-integrated EEG (aEEG) in very preterm infants is affected by perinatal inflammation and brain injury, and correlates with long-term outcome. Methods: Sixteen infants born at 24-28 gestational weeks (median 25.5) had continuous EEG/aEEG during the first 72 h of life. Minimum and maximum EEG interburst intervals (IBI), and aEEG amplitudes were semi-automatically quantified and averaged over the recording period. Neonatal brain injury was diagnosed with repeated cranial ultrasound investigations. Nine cytokines from four time-points were analyzed during the first 72 h (umbilical cord blood, 6, 24 and 72 h), and outcome was assessed at 2 years of corrected age. Results: Infants with neonatal brain injury (n = 9) had prolonged IBI, 11.8 (9.6-23.2) sec versus 8.2 (7.1-11.6) sec in infants (n = 7) without brain damage (p = 0.005). Handicap at 2 years (n = 8, including two infants without neonatally diagnosed brain injury) was associated with prolonged neonatal IBI and lower aEEG amplitudes. Also aEEG amplitudes were decreased in infants with neonatal brain injury. There was a significant positive correlation between the averaged IBI and cord blood TNF-alpha (rs = 0.595, p = 0.025). Conclusion: Early EEG depression is associated with increased cord blood TNF-alpha, neonatal brain damage and handicap at 2 years.}},
author = {{Wikstrom, Sverre and Ley, David and Pupp, Ingrid and Rosén, Ingmar and Hellstrom-Westas, Lena}},
issn = {{1651-2227}},
keywords = {{prognosis; preterm; cytokines; aEEG; brain injury}},
language = {{eng}},
number = {{7}},
pages = {{915--919}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Early amplitude-integrated EEG correlates with cord TNF-alpha and brain injury in very preterm infants}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2008.00787.x}},
doi = {{10.1111/j.1651-2227.2008.00787.x}},
volume = {{97}},
year = {{2008}},
}