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Increased risk of both ulcerative colitis and Crohn's disease in a population suffering from COPD

Ekbom, Anders; Brandt, Lena; Granath, Fredrik; Löfdahl, Claes-Göran LU and Egesten, Arne LU (2008) In Lung 186(3). p.167-172
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways. In the majority of cases, the inflammation is triggered by tobacco smoke. Smoking also affects the pathogenesis of inflammatory bowel disease (IBD), protecting against ulcerative colitis (UC) and promoting development of Crohn's disease (CD). The present study was undertaken to investigate occurrence of IBD among COPD patients, indicating common inflammatory pathways and shared vulnerability on a genetic basis. The study was designed as a population-based cohort study. All individuals discharged with a diagnosis of COPD from 1987 to 2002 were identified in the Swedish Inpatient Register (n = 180,239). Controls and first-degree relatives of... (More)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways. In the majority of cases, the inflammation is triggered by tobacco smoke. Smoking also affects the pathogenesis of inflammatory bowel disease (IBD), protecting against ulcerative colitis (UC) and promoting development of Crohn's disease (CD). The present study was undertaken to investigate occurrence of IBD among COPD patients, indicating common inflammatory pathways and shared vulnerability on a genetic basis. The study was designed as a population-based cohort study. All individuals discharged with a diagnosis of COPD from 1987 to 2002 were identified in the Swedish Inpatient Register (n = 180,239). Controls and first-degree relatives of both cases and controls were identified using the Multi-Generation Register. Finally, all individuals (n = 1,174,557) were compared with the Inpatient Register, identifying discharges with a diagnosis of UC or CD. Hazard ratios (HR) for IBD were determined by Cox proportional hazards regression analysis. COPD patients had a significantly higher risk of both UC (HR 1.83; 95% CI 1.61-2.09) and CD (HR 2.72; 95% CI 2.33-3.18). Among first-degree relatives of COPD patients, there was also an overall increased risk of CD (HR 1.25; 95% CI 1.09-1.43) but not of UC (HR 1.09; 95% CI 0.96-1.23). The kinship of first-degree relatives displayed an increased risk of both UC and CD among siblings (HR 1.49; 95% CI 1.15-1.91 and HR 1.46; 95% CI 1.12-1.89, respectively). The results suggest that COPD and IBD may have inflammatory pathways in common, including genetic variants of genes predisposing for disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
genetics, inflammation, mucosa, COPD, ulcerative colitis, Crohn's disease
in
Lung
volume
186
issue
3
pages
167 - 172
publisher
Springer
external identifiers
  • wos:000256324400005
  • scopus:44449179986
ISSN
1432-1750
DOI
10.1007/s00408-008-9080-z
language
English
LU publication?
yes
id
01e512e4-f77b-42e0-8b8d-98f4297662fa (old id 1201727)
date added to LUP
2008-09-15 12:03:05
date last changed
2017-08-27 04:36:07
@article{01e512e4-f77b-42e0-8b8d-98f4297662fa,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways. In the majority of cases, the inflammation is triggered by tobacco smoke. Smoking also affects the pathogenesis of inflammatory bowel disease (IBD), protecting against ulcerative colitis (UC) and promoting development of Crohn's disease (CD). The present study was undertaken to investigate occurrence of IBD among COPD patients, indicating common inflammatory pathways and shared vulnerability on a genetic basis. The study was designed as a population-based cohort study. All individuals discharged with a diagnosis of COPD from 1987 to 2002 were identified in the Swedish Inpatient Register (n = 180,239). Controls and first-degree relatives of both cases and controls were identified using the Multi-Generation Register. Finally, all individuals (n = 1,174,557) were compared with the Inpatient Register, identifying discharges with a diagnosis of UC or CD. Hazard ratios (HR) for IBD were determined by Cox proportional hazards regression analysis. COPD patients had a significantly higher risk of both UC (HR 1.83; 95% CI 1.61-2.09) and CD (HR 2.72; 95% CI 2.33-3.18). Among first-degree relatives of COPD patients, there was also an overall increased risk of CD (HR 1.25; 95% CI 1.09-1.43) but not of UC (HR 1.09; 95% CI 0.96-1.23). The kinship of first-degree relatives displayed an increased risk of both UC and CD among siblings (HR 1.49; 95% CI 1.15-1.91 and HR 1.46; 95% CI 1.12-1.89, respectively). The results suggest that COPD and IBD may have inflammatory pathways in common, including genetic variants of genes predisposing for disease.},
  author       = {Ekbom, Anders and Brandt, Lena and Granath, Fredrik and Löfdahl, Claes-Göran and Egesten, Arne},
  issn         = {1432-1750},
  keyword      = {genetics,inflammation,mucosa,COPD,ulcerative colitis,Crohn's disease},
  language     = {eng},
  number       = {3},
  pages        = {167--172},
  publisher    = {Springer},
  series       = {Lung},
  title        = {Increased risk of both ulcerative colitis and Crohn's disease in a population suffering from COPD},
  url          = {http://dx.doi.org/10.1007/s00408-008-9080-z},
  volume       = {186},
  year         = {2008},
}