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Neonatal ACE inhibition in rats interferes with lung development.

Lasaitiene, Daina; Chen, Yun; Nannmark, Ulf; Wollmer, Per LU and Friberg, Peter (2004) In Clinical Physiology and Functional Imaging2002-01-01+01:00 24(1). p.65-68
Abstract
The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences postnatal lung development. Rats were given the ACE inhibitor enalapril (10 mg kg-1) from 0 to 9 days of age and their lungs were examined at day 4 and 9. Lung structure was evaluated by means of light microscopy, and surface tension of bronchoalveolar lavage fluid was measured by means of a Wilhelmy balance. Neonatal ACE inhibition lowered the... (More)
The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences postnatal lung development. Rats were given the ACE inhibitor enalapril (10 mg kg-1) from 0 to 9 days of age and their lungs were examined at day 4 and 9. Lung structure was evaluated by means of light microscopy, and surface tension of bronchoalveolar lavage fluid was measured by means of a Wilhelmy balance. Neonatal ACE inhibition lowered the surface tension of bronchoalveolar lavage fluid and caused widening of respiratory airspaces and thinning of alveolar septa. Our results suggest that early postnatal ACE inhibition in rats interferes with lung development. (Less)
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Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
24
issue
1
pages
65 - 68
publisher
Wiley Online Library
external identifiers
  • wos:000188046100009
  • pmid:14717750
  • scopus:1042292615
ISSN
1475-0961
DOI
10.1046/j.1475-0961.2003.00530.x
language
English
LU publication?
yes
id
a02db769-cb0b-4cc4-9db2-71c0c5e83bbf (old id 120194)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14717750&dopt=Abstract
date added to LUP
2007-07-25 10:35:14
date last changed
2017-01-01 04:55:33
@article{a02db769-cb0b-4cc4-9db2-71c0c5e83bbf,
  abstract     = {The renin-angiotensin system (RAS) is developmentally up-regulated and it is essential for kidney development in several species. Given the fact that the rat lung undergoes postnatal development, the mammalian lung possesses the highest angiotensin-converting enzyme (ACE) levels and ACE activity increases during the first weeks postpartum, we tested the hypothesis that ACE inhibition influences postnatal lung development. Rats were given the ACE inhibitor enalapril (10 mg kg-1) from 0 to 9 days of age and their lungs were examined at day 4 and 9. Lung structure was evaluated by means of light microscopy, and surface tension of bronchoalveolar lavage fluid was measured by means of a Wilhelmy balance. Neonatal ACE inhibition lowered the surface tension of bronchoalveolar lavage fluid and caused widening of respiratory airspaces and thinning of alveolar septa. Our results suggest that early postnatal ACE inhibition in rats interferes with lung development.},
  author       = {Lasaitiene, Daina and Chen, Yun and Nannmark, Ulf and Wollmer, Per and Friberg, Peter},
  issn         = {1475-0961},
  language     = {eng},
  number       = {1},
  pages        = {65--68},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Neonatal ACE inhibition in rats interferes with lung development.},
  url          = {http://dx.doi.org/10.1046/j.1475-0961.2003.00530.x},
  volume       = {24},
  year         = {2004},
}