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Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.

Roström, Björn LU ; Grubb, Anders LU and Holmdahl, Rikard LU (2004) In Acta Neurologica Scandinavica 109(2). p.106-112
Abstract
Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).



Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.



Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in... (More)
Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).



Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.



Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in seven of 42 rats. OB was detected in rats with an antibody response against MBP, whereas as a role no such bands were present in rats with an antibody response against MOG. Initially severe disease symptoms were correlated to a concomitant intense oligoclonal antibody response.



Conclusion: Cerebrospinal fluid-specific OB occurs in EAE. It is present in rats with an anti-MBP, but not in rats with an anti-MOG antibody response. A severe disease results in an intense oligoclonal antibody response, which might have an anti-inflammatory effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neurologica Scandinavica
volume
109
issue
2
pages
106 - 112
publisher
Wiley-Blackwell
external identifiers
  • wos:000187850400005
  • pmid:14705972
  • scopus:0842329791
ISSN
1600-0404
DOI
10.1034/j.1600-0404.2003.00187.x
language
English
LU publication?
yes
id
996a7997-09f3-4390-ae05-474b6d50c159 (old id 120332)
date added to LUP
2007-07-06 07:40:08
date last changed
2017-01-01 06:44:31
@article{996a7997-09f3-4390-ae05-474b6d50c159,
  abstract     = {Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE).<br/><br>
<br/><br>
Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detected by electrophoresis of both sera and CSF. The relationship between disease symptoms, antibody response against myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and appearance of OBs was studied.<br/><br>
<br/><br>
Results: Development of CSF-specific OB was found to occur, 6 weeks after immunization, in seven of 42 rats. OB was detected in rats with an antibody response against MBP, whereas as a role no such bands were present in rats with an antibody response against MOG. Initially severe disease symptoms were correlated to a concomitant intense oligoclonal antibody response.<br/><br>
<br/><br>
Conclusion: Cerebrospinal fluid-specific OB occurs in EAE. It is present in rats with an anti-MBP, but not in rats with an anti-MOG antibody response. A severe disease results in an intense oligoclonal antibody response, which might have an anti-inflammatory effect.},
  author       = {Roström, Björn and Grubb, Anders and Holmdahl, Rikard},
  issn         = {1600-0404},
  language     = {eng},
  number       = {2},
  pages        = {106--112},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Neurologica Scandinavica},
  title        = {Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.},
  url          = {http://dx.doi.org/10.1034/j.1600-0404.2003.00187.x},
  volume       = {109},
  year         = {2004},
}