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Amphiregulin: Role in mammary gland development and breast cancer

McBryan, Jean; Howlin, Jillian LU ; Napoletano, Silvia and Martin, Finian (2008) In Journal of Mammary Gland Biology and Neoplasia 13(2). p.159-169
Abstract
Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad. This estrogen-dependent process is believed to be essentially dependent on locally produced growth factors that act in a paracrine fashion. EGF-like growth factor ligands, acting through EGF receptors are some of the principal promoters of pubertal ductal morphogenesis. Amphiregulin is the most abundant EGF-like growth factor in the pubertal mammary gland. Its gene is transcriptionally regulated by ER alpha, and recent evidence identifies it as a key mediator of the estrogen-driven epithelial cell proliferation of puberty: The pubertal deficiency in mammary gland ductal morphogenesis... (More)
Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad. This estrogen-dependent process is believed to be essentially dependent on locally produced growth factors that act in a paracrine fashion. EGF-like growth factor ligands, acting through EGF receptors are some of the principal promoters of pubertal ductal morphogenesis. Amphiregulin is the most abundant EGF-like growth factor in the pubertal mammary gland. Its gene is transcriptionally regulated by ER alpha, and recent evidence identifies it as a key mediator of the estrogen-driven epithelial cell proliferation of puberty: The pubertal deficiency in mammary gland ductal morphogenesis in ER alpha, amphiregulin, and EGFR knockout mice phenocopy each other. As a prognostic indicator in human breast cancer, amphiregulin indicates an outcome identical to that predicted by ER alpha presence. Despite this, a range of studies both on preneoplastic human breast tissue and on cell culture based models of breast cancer, suggest a possibly significant role for amphiregulin in driving human breast cancer progression. Here we summarise our current understanding of amphiregulin's contribution to mammary gland development and breast cancer progression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
puberty, amphiregulin, estrogen, ductal morphogenesis
in
Journal of Mammary Gland Biology and Neoplasia
volume
13
issue
2
pages
159 - 169
publisher
Springer
external identifiers
  • wos:000256028000002
  • scopus:44149084193
ISSN
1083-3021
DOI
10.1007/s10911-008-9075-7
language
English
LU publication?
yes
id
11f965fb-6c17-41fb-aede-875ab50e2df9 (old id 1203371)
date added to LUP
2008-09-15 17:00:37
date last changed
2017-10-22 03:48:32
@article{11f965fb-6c17-41fb-aede-875ab50e2df9,
  abstract     = {Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad. This estrogen-dependent process is believed to be essentially dependent on locally produced growth factors that act in a paracrine fashion. EGF-like growth factor ligands, acting through EGF receptors are some of the principal promoters of pubertal ductal morphogenesis. Amphiregulin is the most abundant EGF-like growth factor in the pubertal mammary gland. Its gene is transcriptionally regulated by ER alpha, and recent evidence identifies it as a key mediator of the estrogen-driven epithelial cell proliferation of puberty: The pubertal deficiency in mammary gland ductal morphogenesis in ER alpha, amphiregulin, and EGFR knockout mice phenocopy each other. As a prognostic indicator in human breast cancer, amphiregulin indicates an outcome identical to that predicted by ER alpha presence. Despite this, a range of studies both on preneoplastic human breast tissue and on cell culture based models of breast cancer, suggest a possibly significant role for amphiregulin in driving human breast cancer progression. Here we summarise our current understanding of amphiregulin's contribution to mammary gland development and breast cancer progression.},
  author       = {McBryan, Jean and Howlin, Jillian and Napoletano, Silvia and Martin, Finian},
  issn         = {1083-3021},
  keyword      = {puberty,amphiregulin,estrogen,ductal morphogenesis},
  language     = {eng},
  number       = {2},
  pages        = {159--169},
  publisher    = {Springer},
  series       = {Journal of Mammary Gland Biology and Neoplasia},
  title        = {Amphiregulin: Role in mammary gland development and breast cancer},
  url          = {http://dx.doi.org/10.1007/s10911-008-9075-7},
  volume       = {13},
  year         = {2008},
}