Breast cancer survival is associated with telomere length in peripheral blood cells
(2008) In Cancer Research 68(10). p.3618-3623- Abstract
- Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95%... (More)
- Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95% confidence interval (95% CI), 3.09-8.64] for the quartile with the longest telomeres. Furthermore, RTL carried prognostic information for patients with advanced disease. Node positive (N+) patients with short telomeres (<= median) showed an increased survival compared with N+ patients with long telomeres (P = 0.001). For patients with ages <50 years with tumors >16 mm (median tumor diameter), short telomeres were associated with a significantly better outcome than longer telomeres (P = 0.006). Cox regression analysis showed that long RTL was a significant independent negative prognostic factor (hazards ratio, 2.92; 95% Cl, 1.33-6.39; P = 0.007). Our results indicate that blood RTL may serve as a prognostic indicator in breast cancer patients with advanced disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1203442
- author
- Svenson, Ulrika ; Nordfjall, Katarina ; Stegmayr, Birgitta ; Manjer, Jonas LU ; Nilsson, Peter ; Tavelin, Bjorn ; Henriksson, Roger ; Lenner, Per and Roos, Goran
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Research
- volume
- 68
- issue
- 10
- pages
- 3618 - 3623
- publisher
- American Association for Cancer Research Inc.
- external identifiers
-
- wos:000255933600013
- scopus:45549102818
- ISSN
- 1538-7445
- DOI
- 10.1158/0008-5472.CAN-07-6497
- language
- English
- LU publication?
- yes
- id
- c5c1c446-d100-4537-ba66-9bed7dfe1068 (old id 1203442)
- date added to LUP
- 2016-04-01 13:37:56
- date last changed
- 2022-04-21 22:42:30
@article{c5c1c446-d100-4537-ba66-9bed7dfe1068,
abstract = {{Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95% confidence interval (95% CI), 3.09-8.64] for the quartile with the longest telomeres. Furthermore, RTL carried prognostic information for patients with advanced disease. Node positive (N+) patients with short telomeres (<= median) showed an increased survival compared with N+ patients with long telomeres (P = 0.001). For patients with ages <50 years with tumors >16 mm (median tumor diameter), short telomeres were associated with a significantly better outcome than longer telomeres (P = 0.006). Cox regression analysis showed that long RTL was a significant independent negative prognostic factor (hazards ratio, 2.92; 95% Cl, 1.33-6.39; P = 0.007). Our results indicate that blood RTL may serve as a prognostic indicator in breast cancer patients with advanced disease.}},
author = {{Svenson, Ulrika and Nordfjall, Katarina and Stegmayr, Birgitta and Manjer, Jonas and Nilsson, Peter and Tavelin, Bjorn and Henriksson, Roger and Lenner, Per and Roos, Goran}},
issn = {{1538-7445}},
language = {{eng}},
number = {{10}},
pages = {{3618--3623}},
publisher = {{American Association for Cancer Research Inc.}},
series = {{Cancer Research}},
title = {{Breast cancer survival is associated with telomere length in peripheral blood cells}},
url = {{http://dx.doi.org/10.1158/0008-5472.CAN-07-6497}},
doi = {{10.1158/0008-5472.CAN-07-6497}},
volume = {{68}},
year = {{2008}},
}