Advanced

Breast cancer survival is associated with telomere length in peripheral blood cells

Svenson, Ulrika; Nordfjall, Katarina; Stegmayr, Birgitta; Manjer, Jonas LU ; Nilsson, Peter; Tavelin, Bjorn; Henriksson, Roger; Lenner, Per and Roos, Goran (2008) In Cancer Research 68(10). p.3618-3623
Abstract
Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95%... (More)
Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95% confidence interval (95% CI), 3.09-8.64] for the quartile with the longest telomeres. Furthermore, RTL carried prognostic information for patients with advanced disease. Node positive (N+) patients with short telomeres (<= median) showed an increased survival compared with N+ patients with long telomeres (P = 0.001). For patients with ages <50 years with tumors >16 mm (median tumor diameter), short telomeres were associated with a significantly better outcome than longer telomeres (P = 0.006). Cox regression analysis showed that long RTL was a significant independent negative prognostic factor (hazards ratio, 2.92; 95% Cl, 1.33-6.39; P = 0.007). Our results indicate that blood RTL may serve as a prognostic indicator in breast cancer patients with advanced disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Research
volume
68
issue
10
pages
3618 - 3623
publisher
American Association for Cancer Research Inc.
external identifiers
  • wos:000255933600013
  • scopus:45549102818
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-07-6497
language
English
LU publication?
yes
id
c5c1c446-d100-4537-ba66-9bed7dfe1068 (old id 1203442)
date added to LUP
2008-09-16 16:21:19
date last changed
2017-08-27 04:40:27
@article{c5c1c446-d100-4537-ba66-9bed7dfe1068,
  abstract     = {Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P &lt; 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95% confidence interval (95% CI), 3.09-8.64] for the quartile with the longest telomeres. Furthermore, RTL carried prognostic information for patients with advanced disease. Node positive (N+) patients with short telomeres (&lt;= median) showed an increased survival compared with N+ patients with long telomeres (P = 0.001). For patients with ages &lt;50 years with tumors &gt;16 mm (median tumor diameter), short telomeres were associated with a significantly better outcome than longer telomeres (P = 0.006). Cox regression analysis showed that long RTL was a significant independent negative prognostic factor (hazards ratio, 2.92; 95% Cl, 1.33-6.39; P = 0.007). Our results indicate that blood RTL may serve as a prognostic indicator in breast cancer patients with advanced disease.},
  author       = {Svenson, Ulrika and Nordfjall, Katarina and Stegmayr, Birgitta and Manjer, Jonas and Nilsson, Peter and Tavelin, Bjorn and Henriksson, Roger and Lenner, Per and Roos, Goran},
  issn         = {1538-7445},
  language     = {eng},
  number       = {10},
  pages        = {3618--3623},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Breast cancer survival is associated with telomere length in peripheral blood cells},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-07-6497},
  volume       = {68},
  year         = {2008},
}