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C6-peptide serology as diagnostic tool in neuroborreliosis

Tjernberg, Ivar; Schon, Thomas; Ernerudh, Jan; Wistedt, Annika Carlsson; Forsberg, Pia and Eliasson, Ingvar LU (2008) In Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 116(5). p.393-399
Abstract
The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >=... (More)
The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >= 12 years with pleocytosis, 94% (51/54) had a positive C6 serology. Of AI-positive patients with a symptom duration of more than 30 days, 93% (27/29) were positive by the C6 test. We conclude that the C6 serum test, together with clinical evaluation, is a powerful diagnostic tool in adult (>= 12 years) European patients with suspected neuroborreliosis with a symptom duration of more than 30 days. Patients with suspected neuroborreliosis and positive C6 results should be further investigated by lumbar puncture for definite diagnosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebrospinal fluid, Lyme neuroborreliosis, serology, pleocytosis, intrathecal antibodies
in
Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
volume
116
issue
5
pages
393 - 399
publisher
John Wiley & Sons
external identifiers
  • wos:000255490600007
  • scopus:43049138377
ISSN
1600-0463
DOI
10.1111/j.1600-0463.2008.00842.x
language
English
LU publication?
yes
id
fc21d756-5721-449a-8b0d-8ce05bf029b3 (old id 1205391)
date added to LUP
2008-09-18 15:22:59
date last changed
2017-07-30 03:50:38
@article{fc21d756-5721-449a-8b0d-8ce05bf029b3,
  abstract     = {The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p &lt; 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged &gt;= 12 years with pleocytosis, 94% (51/54) had a positive C6 serology. Of AI-positive patients with a symptom duration of more than 30 days, 93% (27/29) were positive by the C6 test. We conclude that the C6 serum test, together with clinical evaluation, is a powerful diagnostic tool in adult (&gt;= 12 years) European patients with suspected neuroborreliosis with a symptom duration of more than 30 days. Patients with suspected neuroborreliosis and positive C6 results should be further investigated by lumbar puncture for definite diagnosis.},
  author       = {Tjernberg, Ivar and Schon, Thomas and Ernerudh, Jan and Wistedt, Annika Carlsson and Forsberg, Pia and Eliasson, Ingvar},
  issn         = {1600-0463},
  keyword      = {cerebrospinal fluid,Lyme neuroborreliosis,serology,pleocytosis,intrathecal antibodies},
  language     = {eng},
  number       = {5},
  pages        = {393--399},
  publisher    = {John Wiley & Sons},
  series       = {Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)},
  title        = {C6-peptide serology as diagnostic tool in neuroborreliosis},
  url          = {http://dx.doi.org/10.1111/j.1600-0463.2008.00842.x},
  volume       = {116},
  year         = {2008},
}