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Association of change in physical activity with use of outpatient specialist care and hospitalisations among breast cancer survivors with type 2 diabetes in Sweden

Allen, Genevieve ; Heiland, Emerald G. ; Teleka, Stanley LU ; Glimelius, Ingrid ; Michaëlsson, Karl ; Byberg, Liisa and Brooke, Hannah L. (2025) In British Journal of Cancer 133(5). p.655-664
Abstract

Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self-reported frequency of walking 30 min/week, 1–3 years before and after their breast cancer diagnosis (diagnosed 2004-2018). Women were grouped as: maintained inactive (reference), increased activity, decreased activity, or maintained active. Using multivariable-adjusted Cox proportional hazards models, we assessed change in physical activity... (More)

Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self-reported frequency of walking 30 min/week, 1–3 years before and after their breast cancer diagnosis (diagnosed 2004-2018). Women were grouped as: maintained inactive (reference), increased activity, decreased activity, or maintained active. Using multivariable-adjusted Cox proportional hazards models, we assessed change in physical activity with time to 1) first hospital admission and 2) first outpatient specialist care/hospitalisation for 15 International Classification of Disease chapters in the National Patient Register. Results: Women who maintained active (hazard ratio[95% CI]: 0.68[0.58–0.80]) or increased (0.72[0.58–0.88]) activity, but not those who decreased (0.92[0.79–1.08]) activity, had a lower rate of hospitalisations during follow-up than inactive women. Results were similar for infection, malignancy, blood disorders, general symptoms, mental/behavioural health. Conclusion: In breast cancer survivors, treated with curative intention, with T2DM, maintaining or increasing walking to ≥3times/week was associated with lower rates of hospitalisations overall and specialist outpatient care/hospitalisations across a range of diagnoses. (Figure presented.)

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
133
issue
5
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:40615717
  • scopus:105009613583
ISSN
0007-0920
DOI
10.1038/s41416-025-03099-x
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2025.
id
12053e96-cde8-46b3-9ba0-076f52fd66f1
date added to LUP
2026-01-22 16:32:38
date last changed
2026-01-23 03:00:05
@article{12053e96-cde8-46b3-9ba0-076f52fd66f1,
  abstract     = {{<p>Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self-reported frequency of walking 30 min/week, 1–3 years before and after their breast cancer diagnosis (diagnosed 2004-2018). Women were grouped as: maintained inactive (reference), increased activity, decreased activity, or maintained active. Using multivariable-adjusted Cox proportional hazards models, we assessed change in physical activity with time to 1) first hospital admission and 2) first outpatient specialist care/hospitalisation for 15 International Classification of Disease chapters in the National Patient Register. Results: Women who maintained active (hazard ratio[95% CI]: 0.68[0.58–0.80]) or increased (0.72[0.58–0.88]) activity, but not those who decreased (0.92[0.79–1.08]) activity, had a lower rate of hospitalisations during follow-up than inactive women. Results were similar for infection, malignancy, blood disorders, general symptoms, mental/behavioural health. Conclusion: In breast cancer survivors, treated with curative intention, with T2DM, maintaining or increasing walking to ≥3times/week was associated with lower rates of hospitalisations overall and specialist outpatient care/hospitalisations across a range of diagnoses. (Figure presented.)</p>}},
  author       = {{Allen, Genevieve and Heiland, Emerald G. and Teleka, Stanley and Glimelius, Ingrid and Michaëlsson, Karl and Byberg, Liisa and Brooke, Hannah L.}},
  issn         = {{0007-0920}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{5}},
  pages        = {{655--664}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Association of change in physical activity with use of outpatient specialist care and hospitalisations among breast cancer survivors with type 2 diabetes in Sweden}},
  url          = {{http://dx.doi.org/10.1038/s41416-025-03099-x}},
  doi          = {{10.1038/s41416-025-03099-x}},
  volume       = {{133}},
  year         = {{2025}},
}