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Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters

Bah, Jessica; Lindström, Mats LU ; Westberg, Lars; Manneras, Louise; Ryding, Erik LU ; Henningsson, Susanne; Melke, Jonas; Rosén, Ingmar LU ; Träskman Bendz, Lil LU and Eriksson, Elias (2008) In Psychiatry Research: Neuroimaging 162(3). p.221-229
Abstract
The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the... (More)
The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
suicide, SPECT, STin2, SLC6A4, 5-HTTLPR
in
Psychiatry Research: Neuroimaging
volume
162
issue
3
pages
221 - 229
publisher
Elsevier
external identifiers
  • wos:000255122100005
  • scopus:40249116221
ISSN
0925-4927
DOI
10.1016/j.pscychresns.2007.07.004
language
English
LU publication?
yes
id
914a0434-6616-4865-b963-e3ff1a52fb88 (old id 1205470)
date added to LUP
2008-09-19 09:43:00
date last changed
2017-10-08 03:52:43
@article{914a0434-6616-4865-b963-e3ff1a52fb88,
  abstract     = {The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.},
  author       = {Bah, Jessica and Lindström, Mats and Westberg, Lars and Manneras, Louise and Ryding, Erik and Henningsson, Susanne and Melke, Jonas and Rosén, Ingmar and Träskman Bendz, Lil and Eriksson, Elias},
  issn         = {0925-4927},
  keyword      = {suicide,SPECT,STin2,SLC6A4,5-HTTLPR},
  language     = {eng},
  number       = {3},
  pages        = {221--229},
  publisher    = {Elsevier},
  series       = {Psychiatry Research: Neuroimaging},
  title        = {Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters},
  url          = {http://dx.doi.org/10.1016/j.pscychresns.2007.07.004},
  volume       = {162},
  year         = {2008},
}