Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters
Bah, Jessica ; Lindström, Mats LU
; Westberg, Lars
; Manneras, Louise
; Ryding, Erik
LU
; Henningsson, Susanne
; Melke, Jonas
; Rosén, Ingmar
LU
; Träskman Bendz, Lil
LU
and Eriksson, Elias
(2008)
In Psychiatry Research: Neuroimaging
162(3).
p.221-229
- Abstract
- The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the... (More)
- The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1205470
- author
- Bah, Jessica
; Lindström, Mats
LU
; Westberg, Lars
; Manneras, Louise
; Ryding, Erik
LU
; Henningsson, Susanne
; Melke, Jonas
; Rosén, Ingmar
LU
; Träskman Bendz, Lil
LU
and Eriksson, Elias
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- suicide, SPECT, STin2, SLC6A4, 5-HTTLPR
- in
- Psychiatry Research: Neuroimaging
- volume
- 162
- issue
- 3
- pages
- 221 - 229
- publisher
- Elsevier
- external identifiers
-
- wos:000255122100005
- scopus:40249116221
- pmid:18314311
- ISSN
- 0925-4927
- DOI
- 10.1016/j.pscychresns.2007.07.004
- language
- English
- LU publication?
- yes
- id
- 914a0434-6616-4865-b963-e3ff1a52fb88 (old id 1205470)
- date added to LUP
- 2016-04-01 13:34:01
- date last changed
- 2022-01-27 19:53:01
@article{914a0434-6616-4865-b963-e3ff1a52fb88,
abstract = {{The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence anxiety-related personality traits, as well as the risk of developing depression and suicidality. Serotonin 5-HTT availability was assessed with single photon emission computed tomography (SPECT), using I-123-beta-CIT as ligand, in a population of unmedicated male suicide attempters (n=9) and in matched controls (n=9). Two polymorphisms in SLC6A4 were assessed, including the 5-HTTLPR located in the promoter region and a variable number of tandem repeats (VNTR) polymorphism in intron 2 (STin2). In suicide attempters, but not in controls, low 5-HTT availability was associated with the S allele of 5-HTTLPR and with the 12 repeat allele of STin2. Data suggest that polymorphisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.}},
author = {{Bah, Jessica and Lindström, Mats and Westberg, Lars and Manneras, Louise and Ryding, Erik and Henningsson, Susanne and Melke, Jonas and Rosén, Ingmar and Träskman Bendz, Lil and Eriksson, Elias}},
issn = {{0925-4927}},
keywords = {{suicide; SPECT; STin2; SLC6A4; 5-HTTLPR}},
language = {{eng}},
number = {{3}},
pages = {{221--229}},
publisher = {{Elsevier}},
series = {{Psychiatry Research: Neuroimaging}},
title = {{Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters}},
url = {{http://dx.doi.org/10.1016/j.pscychresns.2007.07.004}},
doi = {{10.1016/j.pscychresns.2007.07.004}},
volume = {{162}},
year = {{2008}},
}