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Poly(hydroxyethyl methacrylate)-based macroporous hydrogels with disulfide cross-linker

Andac, M; Plieva, Fatima LU ; Denizli, A; Galaev, Igor LU and Mattiasson, Bo LU (2008) In Macromolecular Chemistry and Physics 209(6). p.577-584
Abstract
Biodegradable supermacroporous PHEMA cryogels were produced by combining two cross-linkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N'-bis(methacryloyl)-L-cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
poly(hydroxyethyl methacrylate), hydrogels, cryogels, disulfide crosslinker, biodegradable polymers
in
Macromolecular Chemistry and Physics
volume
209
issue
6
pages
577 - 584
publisher
John Wiley & Sons
external identifiers
  • wos:000255236800002
  • scopus:55349111486
ISSN
1521-3935
DOI
10.1002/macp.200700467
language
English
LU publication?
yes
id
ff2c26a0-ed52-4d70-920e-af6fd2ee504a (old id 1205490)
date added to LUP
2008-09-19 09:54:58
date last changed
2017-06-18 03:47:51
@article{ff2c26a0-ed52-4d70-920e-af6fd2ee504a,
  abstract     = {Biodegradable supermacroporous PHEMA cryogels were produced by combining two cross-linkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N'-bis(methacryloyl)-L-cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.},
  author       = {Andac, M and Plieva, Fatima and Denizli, A and Galaev, Igor and Mattiasson, Bo},
  issn         = {1521-3935},
  keyword      = {poly(hydroxyethyl methacrylate),hydrogels,cryogels,disulfide crosslinker,biodegradable polymers},
  language     = {eng},
  number       = {6},
  pages        = {577--584},
  publisher    = {John Wiley & Sons},
  series       = {Macromolecular Chemistry and Physics},
  title        = {Poly(hydroxyethyl methacrylate)-based macroporous hydrogels with disulfide cross-linker},
  url          = {http://dx.doi.org/10.1002/macp.200700467},
  volume       = {209},
  year         = {2008},
}