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The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia

Kaderi, Mohd Arifin; Murray, Fiona; Jansson, Mattias; Merup, Mats; Karlsson, Karin LU ; Ross, Goeran; Aleskog, Anna and Tobin, Gerard (2008) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 32(6). p.984-987
Abstract
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes to clinical outcome and other known prognostic factors such as the immunoglobulin heavy chain variable (IGHV) gene mutation status and CD38 expression. In the present study, no difference in overall survival or time to treatment was observed in the CLL patients with the different genotypes in contrast to the previous report.... (More)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes to clinical outcome and other known prognostic factors such as the immunoglobulin heavy chain variable (IGHV) gene mutation status and CD38 expression. In the present study, no difference in overall survival or time to treatment was observed in the CLL patients with the different genotypes in contrast to the previous report. Furthermore, no correlation was observed with the T393C genotypes and IGHV mutational status, Binet stage or CD38 in this cohort. In summary, our data does not support the use of the T393C GNAS SNP as a clinical prognostic factor in CLL. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
leukemia prognosis, GNAS1 T393C single nucleotide polymorphism, chronic lymphocytic
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
32
issue
6
pages
984 - 987
publisher
Elsevier
external identifiers
  • wos:000255269100021
  • scopus:40749120061
ISSN
1873-5835
DOI
10.1016/j.leukres.2007.10.003
language
English
LU publication?
yes
id
918e966f-38e8-4b8d-ba14-c0650bb2454f (old id 1205497)
date added to LUP
2008-09-19 09:56:53
date last changed
2017-01-01 04:26:50
@article{918e966f-38e8-4b8d-ba14-c0650bb2454f,
  abstract     = {Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes to clinical outcome and other known prognostic factors such as the immunoglobulin heavy chain variable (IGHV) gene mutation status and CD38 expression. In the present study, no difference in overall survival or time to treatment was observed in the CLL patients with the different genotypes in contrast to the previous report. Furthermore, no correlation was observed with the T393C genotypes and IGHV mutational status, Binet stage or CD38 in this cohort. In summary, our data does not support the use of the T393C GNAS SNP as a clinical prognostic factor in CLL.},
  author       = {Kaderi, Mohd Arifin and Murray, Fiona and Jansson, Mattias and Merup, Mats and Karlsson, Karin and Ross, Goeran and Aleskog, Anna and Tobin, Gerard},
  issn         = {1873-5835},
  keyword      = {leukemia prognosis,GNAS1 T393C single nucleotide polymorphism,chronic lymphocytic},
  language     = {eng},
  number       = {6},
  pages        = {984--987},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia},
  url          = {http://dx.doi.org/10.1016/j.leukres.2007.10.003},
  volume       = {32},
  year         = {2008},
}