Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
(2008) In Blood 111(8). p.4096-4105- Abstract
- The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1205580
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 111
- issue
- 8
- pages
- 4096 - 4105
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000255134700032
- scopus:43249087544
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2007-05-089565
- language
- English
- LU publication?
- yes
- id
- 4492e023-ecd3-46da-9298-060ce0907772 (old id 1205580)
- date added to LUP
- 2016-04-01 12:38:06
- date last changed
- 2022-04-29 08:41:15
@article{4492e023-ecd3-46da-9298-060ce0907772, abstract = {{The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.}}, author = {{Tjwa, Marc and Ido-Martin, Lola Bell and Lin, Yuan and Lutgens, Esther and Plaisance, Stephane and Bono, Francoise and Delesque-Touchard, Nathalie and Herve, Caroline and Moura, Rute and Billiau, An D and Aparicio, Cristina and Levi, Marcel and Daemen, Mat and Dewerchin, Mieke and Lupu, Florea and Arnout, Jef and Herbert, Jean-Marc and Waer, Mark and Garcia de Frutos, Pablo and Dahlbäck, Björn and Carmeliet, Peter and Hoylaerts, Marc F and Moons, Lieve}}, issn = {{1528-0020}}, language = {{eng}}, number = {{8}}, pages = {{4096--4105}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes}}, url = {{http://dx.doi.org/10.1182/blood-2007-05-089565}}, doi = {{10.1182/blood-2007-05-089565}}, volume = {{111}}, year = {{2008}}, }