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Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Tjwa, Marc; Ido-Martin, Lola Bell; Lin, Yuan; Lutgens, Esther; Plaisance, Stephane; Bono, Francoise; Delesque-Touchard, Nathalie; Herve, Caroline; Moura, Rute and Billiau, An D, et al. (2008) In Blood 111(8). p.4096-4105
Abstract
The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
111
issue
8
pages
4096 - 4105
publisher
American Society of Hematology
external identifiers
  • wos:000255134700032
  • scopus:43249087544
ISSN
1528-0020
DOI
10.1182/blood-2007-05-089565
language
English
LU publication?
yes
id
4492e023-ecd3-46da-9298-060ce0907772 (old id 1205580)
date added to LUP
2008-09-19 11:26:44
date last changed
2017-10-01 03:59:08
@article{4492e023-ecd3-46da-9298-060ce0907772,
  abstract     = {The role of Gas6 in enclothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and enclothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.},
  author       = {Tjwa, Marc and Ido-Martin, Lola Bell and Lin, Yuan and Lutgens, Esther and Plaisance, Stephane and Bono, Francoise and Delesque-Touchard, Nathalie and Herve, Caroline and Moura, Rute and Billiau, An D and Aparicio, Cristina and Levi, Marcel and Daemen, Mat and Dewerchin, Mieke and Lupu, Florea and Arnout, Jef and Herbert, Jean-Marc and Waer, Mark and Garcia de Frutos, Pablo and Dahlbäck, Björn and Carmeliet, Peter and Hoylaerts, Marc F and Moons, Lieve},
  issn         = {1528-0020},
  language     = {eng},
  number       = {8},
  pages        = {4096--4105},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes},
  url          = {http://dx.doi.org/10.1182/blood-2007-05-089565},
  volume       = {111},
  year         = {2008},
}