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Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.

Nilsson, M; Wang, Jian-Sheng LU ; Wielanek, L; Tanner, K E and Lidgren, Lars LU (2004) In Journal of Bone and Joint Surgery: British Volume 86(1). p.120-125
Abstract
An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces... (More)
An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Bone Substitutes, Biodegradation, Animals, Electron, Muscle, Rats, Rabbits, Skeletal: metabolism, Sprague-Dawley, Scanning, Tibia: metabolism, Calcium Sulfate: metabolism, Durapatite: metabolism, Microscopy
in
Journal of Bone and Joint Surgery: British Volume
volume
86
issue
1
pages
120 - 125
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • wos:000188428700025
  • pmid:14765879
  • scopus:1642504390
ISSN
2044-5377
DOI
10.1302/0301-620X.86B1.14040
language
English
LU publication?
yes
id
9c33554f-126e-4cb8-a31d-84460442e22b (old id 120687)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14765879&dopt=Abstract
date added to LUP
2007-07-03 16:35:24
date last changed
2017-12-05 10:31:37
@article{9c33554f-126e-4cb8-a31d-84460442e22b,
  abstract     = {An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth.},
  author       = {Nilsson, M and Wang, Jian-Sheng and Wielanek, L and Tanner, K E and Lidgren, Lars},
  issn         = {2044-5377},
  keyword      = {Bone Substitutes,Biodegradation,Animals,Electron,Muscle,Rats,Rabbits,Skeletal: metabolism,Sprague-Dawley,Scanning,Tibia: metabolism,Calcium Sulfate: metabolism,Durapatite: metabolism,Microscopy},
  language     = {eng},
  number       = {1},
  pages        = {120--125},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery: British Volume},
  title        = {Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.},
  url          = {http://dx.doi.org/10.1302/0301-620X.86B1.14040},
  volume       = {86},
  year         = {2004},
}