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Skeletal muscle telomere length is not impaired in healthy physically active old women and men

Ponsot, Elodie; Lexell, Jan LU and Kadi, Fawzi (2008) In Muscle and Nerve 37(4). p.467-472
Abstract
We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory... (More)
We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
telomere, satellite cell, regeneration, aging, exercise
in
Muscle and Nerve
volume
37
issue
4
pages
467 - 472
publisher
John Wiley & Sons
external identifiers
  • wos:000254786400008
  • scopus:41849113817
ISSN
0148-639X
DOI
10.1002/mus.20964
language
English
LU publication?
yes
id
431a4ca1-f1c9-4798-bb2d-79917da7395f (old id 1207195)
date added to LUP
2008-08-28 13:07:52
date last changed
2017-09-17 04:28:11
@article{431a4ca1-f1c9-4798-bb2d-79917da7395f,
  abstract     = {We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss.},
  author       = {Ponsot, Elodie and Lexell, Jan and Kadi, Fawzi},
  issn         = {0148-639X},
  keyword      = {telomere,satellite cell,regeneration,aging,exercise},
  language     = {eng},
  number       = {4},
  pages        = {467--472},
  publisher    = {John Wiley & Sons},
  series       = {Muscle and Nerve},
  title        = {Skeletal muscle telomere length is not impaired in healthy physically active old women and men},
  url          = {http://dx.doi.org/10.1002/mus.20964},
  volume       = {37},
  year         = {2008},
}