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Ontogeny of vasotocin-expressing cells in zebrafish: Selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area

Eaton, Jennifer L.; Holmqvist, Bo LU and Glasgow, Eric (2008) In Developmental Dynamics 237(4). p.995-1005
Abstract
The neurohypophysial peptide arginine vasotocin, and its mammalian ortholog arginine vasopressin, influence a wide range of physiological and behavioral responses, including aspects of sexual and social behaviors, osmoregulation, stress response, metabolism, blood pressure, and circadian rhythms. Here, we demonstrate that, in zebrafish (Danio rerio), the vasotocin precursor gene arginine vasotocin-neurophysin (avt) is expressed in two domains in the developing embryo: the dorsal preoptic area and the ventral hypothalamus. In the dorsal preoptic area, avt-expressing cells are intermingled with isotocin-neurophysin (ist) -expressing cells, and these neurons project to the neurohypophysis (posterior pituitary). In the dorsal preoptic area,... (More)
The neurohypophysial peptide arginine vasotocin, and its mammalian ortholog arginine vasopressin, influence a wide range of physiological and behavioral responses, including aspects of sexual and social behaviors, osmoregulation, stress response, metabolism, blood pressure, and circadian rhythms. Here, we demonstrate that, in zebrafish (Danio rerio), the vasotocin precursor gene arginine vasotocin-neurophysin (avt) is expressed in two domains in the developing embryo: the dorsal preoptic area and the ventral hypothalamus. In the dorsal preoptic area, avt-expressing cells are intermingled with isotocin-neurophysin (ist) -expressing cells, and these neurons project to the neurohypophysis (posterior pituitary). In the dorsal preoptic area, the transcriptional regulators orthopedia b (otpb) and simple-minded 1 (siml) are required for expression of both avt and ist. In contrast, olp and siml are not required for avt expression in the ventral hypothalamus. Thus, the development of these two avt expression domains is influenced by separate gene regulatory networks. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pituitary, neuroendocrine, hypothalmus, vasopressin, oxytocin, gene regulation, suprachiasmatic nucleus
in
Developmental Dynamics
volume
237
issue
4
pages
995 - 1005
publisher
John Wiley & Sons
external identifiers
  • wos:000254903700011
  • scopus:42149087150
ISSN
1097-0177
DOI
10.1002/dvdy.21503
language
English
LU publication?
yes
id
d20bb18b-9d8d-41dc-be8f-171c347fb9b0 (old id 1207300)
date added to LUP
2008-08-27 14:15:22
date last changed
2017-11-05 03:49:00
@article{d20bb18b-9d8d-41dc-be8f-171c347fb9b0,
  abstract     = {The neurohypophysial peptide arginine vasotocin, and its mammalian ortholog arginine vasopressin, influence a wide range of physiological and behavioral responses, including aspects of sexual and social behaviors, osmoregulation, stress response, metabolism, blood pressure, and circadian rhythms. Here, we demonstrate that, in zebrafish (Danio rerio), the vasotocin precursor gene arginine vasotocin-neurophysin (avt) is expressed in two domains in the developing embryo: the dorsal preoptic area and the ventral hypothalamus. In the dorsal preoptic area, avt-expressing cells are intermingled with isotocin-neurophysin (ist) -expressing cells, and these neurons project to the neurohypophysis (posterior pituitary). In the dorsal preoptic area, the transcriptional regulators orthopedia b (otpb) and simple-minded 1 (siml) are required for expression of both avt and ist. In contrast, olp and siml are not required for avt expression in the ventral hypothalamus. Thus, the development of these two avt expression domains is influenced by separate gene regulatory networks.},
  author       = {Eaton, Jennifer L. and Holmqvist, Bo and Glasgow, Eric},
  issn         = {1097-0177},
  keyword      = {pituitary,neuroendocrine,hypothalmus,vasopressin,oxytocin,gene regulation,suprachiasmatic nucleus},
  language     = {eng},
  number       = {4},
  pages        = {995--1005},
  publisher    = {John Wiley & Sons},
  series       = {Developmental Dynamics},
  title        = {Ontogeny of vasotocin-expressing cells in zebrafish: Selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area},
  url          = {http://dx.doi.org/10.1002/dvdy.21503},
  volume       = {237},
  year         = {2008},
}