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Normal limits for left ventricular ejection fraction and volumes determined by gated single photon emission computed tomography - a comparison between two quantification methods

Lomsky, Milan; Johansson, Lena; Gjertsson, Peter; Björk, Jonas LU and Edenbrandt, Lars LU (2008) In Clinical Physiology and Functional Imaging 28(3). p.169-173
Abstract
To compare gender-related normal limits for left ventricular (LV) ejection fraction (EF), end-diastolic and end-systolic volumes (EDV and ESV), obtained using two myocardial perfusion-gated single photon emission computed tomography (SPECT) quantification methods. A total of 185 patients were retrospectively selected from a consecutive series of patients examined for coronary artery disease (CAD) or for management of known CAD. Patients were included in the study group if they had normal or probably normal results with stress and rest perfusion imaging and if the combined interpretation of perfusion studies and gated rest studies showed no signs or suspicion of myocardial infarction. The gated SPECT studies were performed using a 2-day... (More)
To compare gender-related normal limits for left ventricular (LV) ejection fraction (EF), end-diastolic and end-systolic volumes (EDV and ESV), obtained using two myocardial perfusion-gated single photon emission computed tomography (SPECT) quantification methods. A total of 185 patients were retrospectively selected from a consecutive series of patients examined for coronary artery disease (CAD) or for management of known CAD. Patients were included in the study group if they had normal or probably normal results with stress and rest perfusion imaging and if the combined interpretation of perfusion studies and gated rest studies showed no signs or suspicion of myocardial infarction. The gated SPECT studies were performed using a 2-day stress/gated rest Tc-99m sestamibi protocol. All patient studies were processed using CAFU and quantitative-gated SPECT (QGS), the two software packages for quantification of gated SPECT images. The lower normal limits for EF were higher for CAFU compared with QGS for both women (59% versus 53%) and men (54% versus 47%). The upper normal limits for EDV were also higher for CAFU compared with QGS for both women (133 versus 107 ml) and men (182 versus 161 ml). The differences between the software packages were small for ESV (women 44 versus 44 ml; men 69 versus 74 ml). Gender-specific normal limits need to be applied for LV EF and volumes determined by gated SPECT. Separate criteria for abnormal LV EF and EDV need to be used for women and men depending on the software package used. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
radionuclide imaging, heart function tests, computer-assisted, gender, reference values
in
Clinical Physiology and Functional Imaging
volume
28
issue
3
pages
169 - 173
publisher
Wiley Online Library
external identifiers
  • wos:000254807900005
  • scopus:42149191300
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2008.00791.x
language
English
LU publication?
yes
id
c7d0e33d-ba0a-4a21-8b2a-70e49a3218db (old id 1207305)
date added to LUP
2008-08-27 14:18:09
date last changed
2017-11-19 03:34:54
@article{c7d0e33d-ba0a-4a21-8b2a-70e49a3218db,
  abstract     = {To compare gender-related normal limits for left ventricular (LV) ejection fraction (EF), end-diastolic and end-systolic volumes (EDV and ESV), obtained using two myocardial perfusion-gated single photon emission computed tomography (SPECT) quantification methods. A total of 185 patients were retrospectively selected from a consecutive series of patients examined for coronary artery disease (CAD) or for management of known CAD. Patients were included in the study group if they had normal or probably normal results with stress and rest perfusion imaging and if the combined interpretation of perfusion studies and gated rest studies showed no signs or suspicion of myocardial infarction. The gated SPECT studies were performed using a 2-day stress/gated rest Tc-99m sestamibi protocol. All patient studies were processed using CAFU and quantitative-gated SPECT (QGS), the two software packages for quantification of gated SPECT images. The lower normal limits for EF were higher for CAFU compared with QGS for both women (59% versus 53%) and men (54% versus 47%). The upper normal limits for EDV were also higher for CAFU compared with QGS for both women (133 versus 107 ml) and men (182 versus 161 ml). The differences between the software packages were small for ESV (women 44 versus 44 ml; men 69 versus 74 ml). Gender-specific normal limits need to be applied for LV EF and volumes determined by gated SPECT. Separate criteria for abnormal LV EF and EDV need to be used for women and men depending on the software package used.},
  author       = {Lomsky, Milan and Johansson, Lena and Gjertsson, Peter and Björk, Jonas and Edenbrandt, Lars},
  issn         = {1475-0961},
  keyword      = {radionuclide imaging,heart function tests,computer-assisted,gender,reference values},
  language     = {eng},
  number       = {3},
  pages        = {169--173},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Normal limits for left ventricular ejection fraction and volumes determined by gated single photon emission computed tomography - a comparison between two quantification methods},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2008.00791.x},
  volume       = {28},
  year         = {2008},
}