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An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Saccharomyces cerevisiae

Sandager, L; Dahlqvist, A; Banas, A; Ståhl, U; Lenman, Marit LU ; Gustavsson, M and Stymne, S (2000) In Biochemical Society Transactions 28(6). p.700-702
Abstract
The major route for the synthesis of triacylglycerol (TAG) in yeast as well as in all TAG-accumulating organisms has been suggested to occur via the acylation of diacylglycerol (DAG) by acyl-CoA:diacylglycerol acyltransferase (DAGAT). Genes encoding DAGAT have been identified in both plant and animal tissues. These genes show strong sequence similarities to genes encoding acyl-CoA:cholesterol acyltransferase (ACAT). So far no Saccharomyces cerevisiae DAGAT gene has been published; however, two ACAT-like genes, ARE1 and ARE2, are present in the yeast genome. Both these genes have been suggested to be involved in the synthesis of sterol esters. We have now shown that the ARE1 gene in yeast also is involved in the synthesis of TAG, whereas... (More)
The major route for the synthesis of triacylglycerol (TAG) in yeast as well as in all TAG-accumulating organisms has been suggested to occur via the acylation of diacylglycerol (DAG) by acyl-CoA:diacylglycerol acyltransferase (DAGAT). Genes encoding DAGAT have been identified in both plant and animal tissues. These genes show strong sequence similarities to genes encoding acyl-CoA:cholesterol acyltransferase (ACAT). So far no Saccharomyces cerevisiae DAGAT gene has been published; however, two ACAT-like genes, ARE1 and ARE2, are present in the yeast genome. Both these genes have been suggested to be involved in the synthesis of sterol esters. We have now shown that the ARE1 gene in yeast also is involved in the synthesis of TAG, whereas the ARE2 gene is more specifically involved in the synthesis of sterol esters. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ACAT, DAGAT, lipid, TAG, yeast
in
Biochemical Society Transactions
volume
28
issue
6
pages
700 - 702
publisher
Biochemical Society
external identifiers
  • scopus:0034473817
ISSN
0300-5127
language
English
LU publication?
no
id
87cac352-c1af-42f8-b368-ed2fff327019 (old id 1209862)
date added to LUP
2008-08-25 14:40:37
date last changed
2017-10-29 03:38:45
@article{87cac352-c1af-42f8-b368-ed2fff327019,
  abstract     = {The major route for the synthesis of triacylglycerol (TAG) in yeast as well as in all TAG-accumulating organisms has been suggested to occur via the acylation of diacylglycerol (DAG) by acyl-CoA:diacylglycerol acyltransferase (DAGAT). Genes encoding DAGAT have been identified in both plant and animal tissues. These genes show strong sequence similarities to genes encoding acyl-CoA:cholesterol acyltransferase (ACAT). So far no Saccharomyces cerevisiae DAGAT gene has been published; however, two ACAT-like genes, ARE1 and ARE2, are present in the yeast genome. Both these genes have been suggested to be involved in the synthesis of sterol esters. We have now shown that the ARE1 gene in yeast also is involved in the synthesis of TAG, whereas the ARE2 gene is more specifically involved in the synthesis of sterol esters.},
  author       = {Sandager, L and Dahlqvist, A and Banas, A and Ståhl, U and Lenman, Marit and Gustavsson, M and Stymne, S},
  issn         = {0300-5127},
  keyword      = {ACAT,DAGAT,lipid,TAG,yeast},
  language     = {eng},
  number       = {6},
  pages        = {700--702},
  publisher    = {Biochemical Society},
  series       = {Biochemical Society Transactions},
  title        = {An acyl-CoA:cholesterol acyltransferase (ACAT)-related gene is involved in the accumulation of triacylglycerols in Saccharomyces cerevisiae},
  volume       = {28},
  year         = {2000},
}