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The pigmented life of a redhead.

Rorsman, Hans LU (2004) In Pigment Cell Research1987-01-01+01:002008-01-01+01:00 17(2). p.191-202
Abstract
As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are... (More)
As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pigment Cell Research1987-01-01+01:002008-01-01+01:00
volume
17
issue
2
pages
191 - 202
publisher
Wiley-Blackwell
external identifiers
  • wos:000220175000014
  • pmid:15016311
  • scopus:1842525328
ISSN
0893-5785
DOI
10.1111/j.1600-0749.2003.00127.x
language
English
LU publication?
yes
id
27fdcdcd-3aa1-4a32-90ee-10e9b6722eb4 (old id 121331)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15016311&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2007-07-03 09:00:56
date last changed
2017-01-01 04:20:38
@article{27fdcdcd-3aa1-4a32-90ee-10e9b6722eb4,
  abstract     = {As a redhead I have had a personal interest in red hair, freckles and sunburns since childhood. An observation of a formaldehyde-induced fluorescence in human epidermal melanocytes initiated my scientific interest in these cells. Prota and Nicolaus demonstrated that oxidation products of cysteinyldopas are the main components of pheomelanin. Our identification of 5-S-cysteinyldopa as the source of formaldehyde-induced fluorescence of normal and pathological melanocytes started a series of investigations into this amino acid, enzymatic and non-enzymatic oxidation of catecholic compounds and the metabolism of thiols. All melanocytes with functioning tyrosinase produce cysteinyldopas and the levels of 5-S-cysteinyldopa in serum and urine are related to the size and pigment forming activity of the melanocyte population. The determination of 5-S-cysteinyldopa in serum or urine is a sensitive diagnostic method in the detection of melanoma metastasis. Some non-specific formation of cysteinyldopa is present in the body, as demonstrated by 5-S-cysteinyldopa in individuals with tyrosinase-negative albinism.},
  author       = {Rorsman, Hans},
  issn         = {0893-5785},
  language     = {eng},
  number       = {2},
  pages        = {191--202},
  publisher    = {Wiley-Blackwell},
  series       = {Pigment Cell Research1987-01-01+01:002008-01-01+01:00},
  title        = {The pigmented life of a redhead.},
  url          = {http://dx.doi.org/10.1111/j.1600-0749.2003.00127.x},
  volume       = {17},
  year         = {2004},
}